Association of Mean Platelet Volume and Red Blood Cell Distribution Width with Coronary Collateral Development in Stable Coronary Artery Disease

Overview

Journal Postepy Kardiol Interwencyjnej

Publisher Termedia

Specialty Cardiology & Vascular Diseases

Date 2018 Oct 11

PMID 30302102

Citations 25

Authors

Isa Sincer

Yilmaz Gunes

Asli Kurtar Mansiroglu

Mehmet Cosgun

Gulali Aktas

Affiliations

Soon will be listed here.

Abstract

Introduction: The prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature.

Aim: In this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis.

Material And Methods: A total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD ( = 214) and a group with impaired CCD ( = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography.

Results: The MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 ±1.8 fl vs. 8.7 ±1.9 fl, < 0.001 and 0.06 ±0.08 vs. 0.05 ±0.07, = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 ±1.7% vs. 15.0 ±1.9%, = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading ( = -0.523, < 0.001 and = -0.239, < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD.

Conclusions: The present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.

Citing Articles

Incidence and predictors of new-onset atrial fibrillation in ST-elevation myocardial infarction: A single-center study.

Zarei B, Bozorgi A, Khoshfetrat M, Arefizadeh R, Mohsenizadeh S, Mousavi S Health Sci Rep. 2024; 7(7):e2226.

PMID: 38957860 PMC: 11217016. DOI: 10.1002/hsr2.2226.

Association of Biomarkers for Dyslipidemia, Inflammation, and Oxidative Stress with Endothelial Dysfunction in Obese Youths: A Case-Control Study.

Sharma C, Suliman A, Al Hamad S, Yasin J, Abuzakouk M, Alkaabi J Diabetes Metab Syndr Obes. 2024; 17:2533-2545.

PMID: 38915900 PMC: 11194285. DOI: 10.2147/DMSO.S458233.

High Urine Albumin-to-Creatinine Ratio is Associated with Increased Arterial Stiffness in Diabetes: A Chinese Cross-Sectional Study.

Guo K, Zhu Y, Yu Q, Chen H, Cheng W, Zhang X Diabetes Metab Syndr Obes. 2024; 17:2121-2133.

PMID: 38803641 PMC: 11129741. DOI: 10.2147/DMSO.S457883.

A Prediction Model Based on Systemic Immune-Inflammatory Index Combined with Other Predictors for Major Adverse Cardiovascular Events in Acute Myocardial Infarction Patients.

Li X, Yu C, Liu X, Chen Y, Wang Y, Liang H J Inflamm Res. 2024; 17:1211-1225.

PMID: 38410422 PMC: 10895983. DOI: 10.2147/JIR.S443153.

Association between red cell distribution width-and-albumin ratio and the risk of peripheral artery disease in patients with diabetes.

Li D, Long J, Zhang J, He M, Zeng Q, He Q Front Endocrinol (Lausanne). 2024; 15:1272573.

PMID: 38405142 PMC: 10884210. DOI: 10.3389/fendo.2024.1272573.

References

Park Y, Schoene N, Harris W . Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2002; 13(5-6):301-6. DOI: 10.1080/095371002220148332. View

Cure M, Cure E, Kirbas A, Cicek A, Yuce S . The effects of Gilbert's syndrome on the mean platelet volume and other hematological parameters. Blood Coagul Fibrinolysis. 2013; 24(5):484-8. DOI: 10.1097/MBC.0b013e32835e4230. View

Young Ju H, Kim J, Hur S, Woo S, Park K, Park M . Could mean platelet volume be a promising biomarker of progression of chronic kidney disease?. Platelets. 2014; 26(2):143-7. DOI: 10.3109/09537104.2014.890179. View

Imhof B, Aurrand-Lions M . Angiogenesis and inflammation face off. Nat Med. 2006; 12(2):171-2. DOI: 10.1038/nm0206-171. View

Ghaffari S, Pourafkari L, Javadzadegan H, Masoumi N, Jafarabadi M, Nader N . Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction. Thromb Res. 2015; 136(1):101-6. DOI: 10.1016/j.thromres.2015.05.003. View

Kamath S, Blann A, Lip G . Platelet activation: assessment and quantification. Eur Heart J. 2001; 22(17):1561-71. DOI: 10.1053/euhj.2000.2515. View

Pekdemir H, Polat G, Cin V, Camsari A, Cicek D, Akkus M . Elevated plasma endothelin-1 levels in coronary sinus during rapid right atrial pacing in patients with slow coronary flow. Int J Cardiol. 2004; 97(1):35-41. DOI: 10.1016/j.ijcard.2003.06.025. View

Thompson C, Eaton K, Princiotta S, Rushin C, Valeri C . Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol. 1982; 50(3):509-19. DOI: 10.1111/j.1365-2141.1982.tb01947.x. View

Bulur S, Onder H, Aslantas Y, Ekinozu I, Kilic A, Yalcin S . Relation between indices of end-organ damage and mean platelet volume in hypertensive patients. Blood Coagul Fibrinolysis. 2012; 23(5):367-9. DOI: 10.1097/MBC.0b013e32835291b1. View

10.

Perlstein T, Weuve J, Pfeffer M, Beckman J . Red blood cell distribution width and mortality risk in a community-based prospective cohort. Arch Intern Med. 2009; 169(6):588-94. PMC: 3387573. DOI: 10.1001/archinternmed.2009.55. View

11.

Rentrop K, Thornton J, Feit F, Van Buskirk M . Determinants and protective potential of coronary arterial collaterals as assessed by an angioplasty model. Am J Cardiol. 1988; 61(10):677-84. DOI: 10.1016/0002-9149(88)91048-x. View

12.

Kurtul A, Yarlioglues M, Murat S, Ergun G, Duran M, Kasapkara H . Usefulness of the platelet-to-lymphocyte ratio in predicting angiographic reflow after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. Am J Cardiol. 2014; 114(3):342-7. DOI: 10.1016/j.amjcard.2014.04.045. View

13.

Cure E, Balik M, Cumhur Cure M, Guvercin Y, Erkut A, Yuce S . Is the mean platelet volume predictive of hip fractures in the elderly?. Ann Lab Med. 2013; 33(5):367-70. PMC: 3756244. DOI: 10.3343/alm.2013.33.5.367. View

14.

Corash L, Tan H, Gralnick H . Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure. Blood. 1977; 49(1):71-87. View

15.

Celik T, Celik M, Iyisoy A . [Coronary collateral circulation]. Turk Kardiyol Dern Ars. 2011; 38(7):505-14. View

16.

Tanboga I, Topcu S, Nacar T, Aksakal E, Kalkan K, Kiki I . Relation of coronary collateral circulation with red cell distribution width in patients with non-ST elevation myocardial infarction. Clin Appl Thromb Hemost. 2012; 20(4):411-5. DOI: 10.1177/1076029612470490. View

17.

Werner G, Ferrari M, Heinke S, Kuethe F, Surber R, Richartz B . Angiographic assessment of collateral connections in comparison with invasively determined collateral function in chronic coronary occlusions. Circulation. 2003; 107(15):1972-7. DOI: 10.1161/01.CIR.0000061953.72662.3A. View

18.

Li S, Salhany K . Spurious elevation of automated platelet counts in secondary acute monocytic leukemia associated with tumor lysis syndrome. Arch Pathol Lab Med. 1999; 123(11):1111-4. DOI: 10.5858/1999-123-1111-SEOAPC. View

19.

Duffy B, Gurm H, Rajagopal V, Gupta R, Ellis S, Bhatt D . Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol. 2006; 97(7):993-6. DOI: 10.1016/j.amjcard.2005.10.034. View

20.

Martin J, Shaw T, Heggie J, Penington D . Measurement of the density of human platelets and its relationship to volume. Br J Haematol. 1983; 54(3):337-52. DOI: 10.1111/j.1365-2141.1983.tb02109.x. View