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Primary Gastric Small Cell Carcinoma (Presenting As Linitis Plastica) Diagnosed Using Endoscopic Ultrasound-Guided Biopsy: A Case Report

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Journal Clin Endosc
Date 2018 Oct 10
PMID 30300982
Citations 2
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Abstract

Small cell carcinomas are the most aggressive, highly malignant neuroendocrine tumors; among these, gastric small cell carcinoma (GSCC) is extremely rare. Here we report a case of a patient with primary GSCC, presenting as linitis plastic, who was diagnosed using endoscopic ultrasound (EUS)-guided biopsy. With undiagnosed linitis plastica, an 80-year-old woman was referred to our institution. Abdominal computed tomography revealed irregular wall thickening extending from the gastric body to the antrum. Endoscopy suspected to have Borrmann type IV advanced gastric cancer. EUS of the stomach showed diffuse submucosal thickening of the gastric wall, mainly the antrum. EUS-guided bite-on-bite biopsy confirmed the diagnosis of GSCC. In general, GSCC is difficult to diagnose and careful examination is necessary to determine the therapeutic strategy; however, EUS is particularly helpful in the differential diagnosis of a lesion presenting as linitis plastica.

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References
1.
Kusayanagi S, Konishi K, Miyasaka N, Sasaki K, Kurahashi T, Kaneko K . Primary small cell carcinoma of the stomach. J Gastroenterol Hepatol. 2003; 18(6):743-7. DOI: 10.1046/j.1440-1746.2003.02822.x. View

2.
Brenner B, Tang L, Klimstra D, Kelsen D . Small-cell carcinomas of the gastrointestinal tract: a review. J Clin Oncol. 2004; 22(13):2730-9. DOI: 10.1200/JCO.2004.09.075. View

3.
Nakamura Y, Otani S, Otaka M, Shimada T, Takahashi S, Saito M . Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy. Int J Clin Oncol. 2005; 10(5):348-52. DOI: 10.1007/s10147-005-0492-y. View

4.
Namikawa T, Kobayashi M, Okabayashi T, Ozaki S, Nakamura S, Yamashita K . Primary gastric small cell carcinoma: report of a case and review of the literature. Med Mol Morphol. 2005; 38(4):256-61. DOI: 10.1007/s00795-005-0293-4. View

5.
Kim K, Lee H, Chun S, Shin S, Kim M, Lee K . Clinical overview of extrapulmonary small cell carcinoma. J Korean Med Sci. 2006; 21(5):833-7. PMC: 2721992. DOI: 10.3346/jkms.2006.21.5.833. View