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The Pro Alpha 2(V) Collagen Gene is Evolutionarily Related to the Major Fibrillar-forming Collagens

Overview
Specialty Biochemistry
Date 1987 Jan 12
PMID 3029669
Citations 14
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Abstract

A number of overlapping cDNA clones, covering 5.2 kb of sequences which code for the human pro alpha 2(V) collagen chain, have been isolated. Analysis of the structural data have indicated a close evolutionary kinship between the pro alpha 2(V) chain and the major fibrillar collagen types. Isolation and analysis of an 8 kb genomic fragment has further supported this notion by revealing a homologous arrangement of nine triple-helical domain exons. These studies have therefore provided conclusive evidence which categorizes the Type V collagen as a member of the Group 1 molecules, or fibrillar-forming collagens.

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