An Overview of The Globozoospermia As A Multigenic Identified Syndrome

Overview

Journal Int J Fertil Steril

Specialty Reproductive Medicine

Date 2018 Oct 7

PMID 30291685

Citations 13

Authors

Parastoo Modarres

Marziyeh Tavalaee

Kamran Ghaedi

Mohammad Hossein Nasr-Esfahani

Affiliations

Soon will be listed here.

Abstract

Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN), acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phenomenon referred to globozoospermia.

Citing Articles

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Atypical structure of the nuclear membrane, distribution of nuclear pores and lamin B1 in spermatozoa of patients with complete and partial globozoospermia.

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