» Articles » PMID: 30291147

Technobiology's Enabler: The Magnetoelectric Nanoparticle

Overview
Specialty General Medicine
Date 2018 Oct 7
PMID 30291147
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

To enable patient- and disease-specific diagnostic and treatment at the intracellular level in real time, it is imperative to engineer a perfect way to locally stimulate selected individual neurons, navigate and dispense a cargo of biomolecules into damaged cells or image sites with relatively high efficacy and with adequate spatial and temporal resolutions. Significant progress has been made using biotechnology; especially with the development of bioinformatics, there are endless molecular databases to identify biomolecules to target almost any disease-specific biomarker. Conversely, the technobiology approach that exploits advanced engineering to control underlying molecular mechanisms to recover biosystem's energy states at the molecular level as well as at the level of the entire network of cells (i.e., the internet of the human body) is still in its early research stage. The recently developed magnetoelectric nanoparticles (MENPs) provide a tool to enable the unique capabilities of technobiology. Using exemplary studies that could potentially lead to future pinpoint treatment and prevention of cancer, neurodegenerative diseases, and HIV, this article discusses how MENPs could become a vital enabling tool of technobiology.

Citing Articles

Foundational insights for theranostic applications of magnetoelectric nanoparticles.

Andre V, Abdel-Mottaleb M, Shotbolt M, Chen S, Ramezini Z, Zhang E Nanoscale Horiz. 2025; .

PMID: 39898755 PMC: 11789716. DOI: 10.1039/d4nh00560k.


Magnetoelectrics for Implantable Bioelectronics: Progress to Date.

Alrashdan F, Yang K, Robinson J Acc Chem Res. 2024; 57(20):2953-2962.

PMID: 39366673 PMC: 11483720. DOI: 10.1021/acs.accounts.4c00307.


Advances in Brain Stimulation, Nanomedicine and the Use of Magnetoelectric Nanoparticles: Dopaminergic Alterations and Their Role in Neurodegeneration and Drug Addiction.

Gimenez S, Millan A, Mora-Morell A, Ayuso N, Gastaldo-Jordan I, Pardo M Molecules. 2024; 29(15).

PMID: 39124985 PMC: 11314096. DOI: 10.3390/molecules29153580.


Magnetic Field Intervention Enhances Cellular Migration Rates in Biological Scaffolds.

Vecheck A, McNamee C, Reijo Pera R, Usselman R Bioengineering (Basel). 2024; 11(1).

PMID: 38247887 PMC: 10813414. DOI: 10.3390/bioengineering11010009.


Modulating cell signalling in vivo with magnetic nanotransducers.

Romero G, Park J, Koehler F, Pralle A, Anikeeva P Nat Rev Methods Primers. 2023; 2.

PMID: 38111858 PMC: 10727510. DOI: 10.1038/s43586-022-00170-2.


References
1.
Pridgen E, Langer R, Farokhzad O . Biodegradable, polymeric nanoparticle delivery systems for cancer therapy. Nanomedicine (Lond). 2007; 2(5):669-80. DOI: 10.2217/17435889.2.5.669. View

2.
Coenen A . Neuronal activities underlying the electroencephalogram and evoked potentials of sleeping and waking: implications for information processing. Neurosci Biobehav Rev. 1995; 19(3):447-63. DOI: 10.1016/0149-7634(95)00010-c. View

3.
Ziskin M, Alekseev S, Foster K, Balzano Q . Tissue models for RF exposure evaluation at frequencies above 6 GHz. Bioelectromagnetics. 2018; 39(3):173-189. DOI: 10.1002/bem.22110. View

4.
Grafton S, Mazziotta J, Presty S, Friston K, Frackowiak R, Phelps M . Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET. J Neurosci. 1992; 12(7):2542-8. PMC: 6575851. View

5.
Li S, Wang C, Chu X, Miao G, Xue Q, Zou W . Engineering optical mode ferromagnetic resonance in FeCoB films with ultrathin Ru insertion. Sci Rep. 2016; 6:33349. PMC: 5024132. DOI: 10.1038/srep33349. View