The TLR1 Gene is Associated with Higher Protection from Leprosy in Women

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Oct 6

PMID 30289892

Citations 4

Authors

Eyleen Nabyla Alvarenga Niitsuma

Gabriel da Rocha Fernandes

Francisco Carlos Felix Lana

Affiliations

Soon will be listed here.

Abstract

Leprosy is an infectious disease with a complex genetic and immunological background. Polymorphisms in genes that encode cytokines and receptors involved in the immune response, such as the Toll-like receptor 1 (TLR1), may be associated with disease risk. We hypothesized that polymorphisms in innate immunity genes confer susceptibility to leprosy that differs between women and men. In this study, we investigate sex differences in the association between a single nucleotide polymorphism (SNP) in TLR1 and Nucleotide-binding oligomerization domain containing 2 (NOD2) genes and leprosy susceptibility in 256 clinically classified leprosy patients and 233 control subjects in a Brazilian population. Our results showed no association between the SNP rs8057341 in NOD2 and leprosy in this population. However, the heterozygous genotype of the TLR1 SNP (rs4833095) showed a statistically significant association in women (OR = 0.54, P = 0.02). Our findings suggest that the TLR1 polymorphism was associated with an increased protection from leprosy in women.

Citing Articles

MicroRNA biomarkers in leprosy: insights from the Northern Brazilian Amazon population and their implications in disease immune-physiopathology.

Caceres-Duran M, Pinto P, Magalhaes L, Piedade de Souza T, Gobbo A, Barreto J Front Genet. 2024; 15:1320161.

PMID: 38343694 PMC: 10854011. DOI: 10.3389/fgene.2024.1320161.

Leprosy Neuropathy in a Non-Endemic Area: A Clinical and Pathological Study.

Piccinelli S, Tagliapietra M, Cavallaro T, Labella B, Risi B, Caria F Biomedicines. 2023; 11(9).

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Evaluation of Polymorphisms in Toll-Like Receptor Genes as Biomarkers of the Response to Treatment of Erythema Nodosum Leprosum.

Maciel-Fiuza M, Costa P, Kowalski T, Schuler-Faccini L, Bonamigo R, Vetoratto R Front Med (Lausanne). 2022; 8:713143.

PMID: 35141236 PMC: 8819000. DOI: 10.3389/fmed.2021.713143.

Identification of sensitive indicators in immune response for leprosy affected patients: An observational clinical study of safety and immunogenicity of influenza vaccine.

Zheng Y, Xing H, Zhu Z, Zhu H, Zhang F, Gao X Medicine (Baltimore). 2021; 100(31):e26744.

PMID: 34397815 PMC: 8341344. DOI: 10.1097/MD.0000000000026744.

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