Health-related Quality of Life in Patients with Autoimmune Hepatitis: A Questionnaire Survey

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Oct 5

PMID 30286131

Citations 12

Authors

Atsushi Takahashi

Kei Moriya

Hiromasa Ohira

Teruko Arinaga-Hino

Mikio Zeniya

Takuji Torimura

Masanori Abe

Akinobu Takaki

Jong-Hon Kang

Ayano Inui

Tomoo Fujisawa

Kaname Yoshizawa

Yoshiyuki Suzuki

Nobuhiro Nakamoto

Kazuhiko Koike

Hitoshi Yoshiji

Aya Goto

Atsushi Tanaka

Zobair M Younossi

Hajime Takikawa

Affiliations

Soon will be listed here.

Abstract

Aim: Health-related quality of life is impaired in patients with autoimmune hepatitis, but the association between health-related quality of life and patients' backgrounds remains unknown. We assessed health-related quality of life in patients with autoimmune hepatitis and identified factors associated with its impairment.

Methods: We assessed health-related quality of life in patients with autoimmune hepatitis, patients with chronic hepatitis C, and healthy subjects using the Japanese version of the Chronic Liver Disease Questionnaire and the 36-Item Short Form Survey. We compared health-related quality of life in patients with autoimmune hepatitis with that of patients with chronic hepatitis C and healthy subjects.

Results: A total of 265 patients with autoimmune hepatitis, 88 patients with chronic hepatitis C, and 97 healthy subjects were enrolled; most patients were women. The median ages of patients were 65, 66, and 57 years, respectively. Of these patients with autoimmune hepatitis, 10.6% and 57.0% had cirrhosis and comorbid diseases, respectively. The overall Chronic Liver Disease Questionnaire scores (5.5 vs. 6.2, P < 0.001) and physical (48.1 vs. 54.2, P < 0.001) and mental (51.8 vs. 55.0, P = 0.004) component summaries of 36-Item Short Form Survey were significantly lower in patients with autoimmune hepatitis than in healthy subjects, and similar to scores in patients with chronic hepatitis C. Having cirrhosis, comorbid diseases, and treatment for autoimmune hepatitis were associated with impaired health-related quality of life among patients with autoimmune hepatitis. In particular, prednisolone use was associated with lower scores on the worry domain of the Chronic Liver Disease Questionnaire.

Conclusions: Patients with autoimmune hepatitis showed impairment in health-related quality of life, which was associated with not only disease progression, but also comorbid diseases and treatment. Ways to improve health-related quality of life should be considered in patients with AIH when disease outcome is not favorable and when using prednisolone.

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