Efficacy of Intravenous Acetaminophen in Length of Stay and Postoperative Pain Control in Laparoscopic Roux-en-Y Gastric Bypass Surgery Patients

Overview

Journal Bariatr Surg Pract Patient Care

Date 2018 Oct 5

PMID 30283730

Citations 2

Authors

Matthew Lange

Christina W Lee

Tara Knisely

Subbaiah Perla

Kimberly Barber

Michael Kia

Affiliations

Soon will be listed here.

Abstract

Opiate-based pain medications may incur adverse effects following bariatric surgery. The aim of this study was to evaluate the efficacy of intravenous Acetaminophen (IVAPAP) on length of stay (LOS) after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery. This was a prospective, double-blind, randomized controlled trial conducted from October 2011 to March 2014 at a 416-bed teaching hospital. Eighty-nine total patients were included (control group, = 45; treatment group, = 44). Patients were administered either 1000 mg of IVAPAP or placebo every 6 h beginning preoperatively and continuing for four doses. LOS, total narcotic consumption, pain and nausea scores, time to return of flatus (ROF), and postoperative rescue pain medication used were measured during the first 24 h after surgery. LOS was significantly decreased in the treatment group compared with control (2.72 days vs. 3.18 days; = 0.03). There was significant reduction in time to ROF (1.87 days vs. 2.24 days; = 0.04). Pain was significantly decreased in the first 2 postoperative hours in the treatment group ( = 0.02). Total opioid consumption, postoperative nausea scores, and use of rescue pain medications were not affected. The use of IVAPAP significantly decreases LOS following LRYGB, improves acute postoperative pain control, and mediates quicker return of bowel function.

Citing Articles

Non-Opioid Analgesics and Adjuvants after Surgery in Adults with Obesity: Systematic Review with Network Meta-Analysis of Randomized Controlled Trials.

Carron M, Tamburini E, Linassi F, Pettenuzzo T, Boscolo A, Navalesi P J Clin Med. 2024; 13(7).

PMID: 38610865 PMC: 11012569. DOI: 10.3390/jcm13072100.

Intravenous Acetaminophen Versus Placebo in Post-bariatric Surgery Multimodal Pain Management: a Meta-analysis of Randomized Controlled Trials.

Lee Y, Yu J, Doumouras A, Ashoorion V, Gmora S, Anvari M Obes Surg. 2019; 29(4):1420-1428.

PMID: 30726545 DOI: 10.1007/s11695-019-03732-8.

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