Anesthetic Management in Corpus Callosum Agenesis

Overview

Journal Anesth Essays Res

Specialty Anesthesiology

Date 2018 Oct 5

PMID 30283190

Citations 1

Authors

Ebru Tarikci Kilic

Mehmet Erdem Akcay

Mehmet Salim Akdemir

Egemen Atag

Onur Gursu

Affiliations

Soon will be listed here.

Abstract

Corpus callosum agenesis develops when the band which connects the two hemispheres of the brain does not occur in utero. It is associated with prenatal infections, genetic factors, toxic exposures, metabolic disorders, and chromosome errors. Mostly seen clinical features are macrocephaly, microcephaly, seizures, motor retardation, hypotonia, eye anomalies, and facial dysmorphisms. Here, we report a case of corpus callosum agenesis syndrome undergoing upper endoscopy under deep sedation with dexmedetomidine. The main anesthetic concerns are difficulty in airway, respiratory problems, gastric reflux, and interaction of the seizures therapy with general anesthetics.

Citing Articles

Patent Ductus Arteriosus in Association With Agenesis of Corpus Callosum: Syndromic Links, Difficult Airway Challenges, and Pediatric Anesthesia Management.

Sawant U, Sen J, Wadaskar D Cureus. 2024; 16(6):e63177.

PMID: 39070397 PMC: 11273177. DOI: 10.7759/cureus.63177.

References

Brown W, Symingtion M, VanLancker-Sidtis D, Dietrich R, Paul L . Paralinguistic processing in children with callosal agenesis: emergence of neurolinguistic deficits. Brain Lang. 2005; 93(2):135-9. DOI: 10.1016/j.bandl.2004.09.003. View

Taylor M, David A . Agenesis of the corpus callosum: a United Kingdom series of 56 cases. J Neurol Neurosurg Psychiatry. 1998; 64(1):131-4. PMC: 2169913. DOI: 10.1136/jnnp.64.1.131. View

Chowdhury T, Singh G, Bharti S, Prabhakar H . Anesthetic challenges during perioperative management of patient undergoing repair of basal encephalocele with cleft palate. Saudi J Anaesth. 2012; 6(3):305-7. PMC: 3498680. DOI: 10.4103/1658-354X.101233. View

Wahl M, Strominger Z, Jeremy R, Barkovich A, Wakahiro M, Sherr E . Variability of homotopic and heterotopic callosal connectivity in partial agenesis of the corpus callosum: a 3T diffusion tensor imaging and Q-ball tractography study. AJNR Am J Neuroradiol. 2008; 30(2):282-9. PMC: 7051413. DOI: 10.3174/ajnr.A1361. View

Badaruddin D, Andrews G, Bolte S, Schilmoeller K, Schilmoeller G, Paul L . Social and behavioral problems of children with agenesis of the corpus callosum. Child Psychiatry Hum Dev. 2007; 38(4):287-302. DOI: 10.1007/s10578-007-0065-6. View

Cakir M, Mungan I, Makuloglu M, Okten A . Hydrocephalus with cleft lip and palate: an overlap between midline malformation syndromes. Indian J Pediatr. 2006; 73(8):731-3. DOI: 10.1007/BF02898455. View

Moutard M, Kieffer V, Feingold J, Kieffer F, Lewin F, Adamsbaum C . Agenesis of corpus callosum: prenatal diagnosis and prognosis. Childs Nerv Syst. 2003; 19(7-8):471-6. DOI: 10.1007/s00381-003-0781-6. View

Thauvin-Robinet C, Cossee M, Cormier-Daire V, Van Maldergem L, Toutain A, Alembik Y . Clinical, molecular, and genotype-phenotype correlation studies from 25 cases of oral-facial-digital syndrome type 1: a French and Belgian collaborative study. J Med Genet. 2006; 43(1):54-61. PMC: 2564504. DOI: 10.1136/jmg.2004.027672. View

Bedeschi M, Bonaglia M, Grasso R, Pellegri A, Garghentino R, Battaglia M . Agenesis of the corpus callosum: clinical and genetic study in 63 young patients. Pediatr Neurol. 2006; 34(3):186-93. DOI: 10.1016/j.pediatrneurol.2005.08.008. View

10.

Gentile M, Di Carlo A, Volpe P, Pansini A, Nanna P, Valenzano M . FISH and cytogenetic characterization of a terminal chromosome 1q deletion: clinical case report and phenotypic implications. Am J Med Genet A. 2003; 117A(3):251-4. DOI: 10.1002/ajmg.a.10018. View

11.

Devinsky O, Laff R . Callosal lesions and behavior: history and modern concepts. Epilepsy Behav. 2003; 4(6):607-17. DOI: 10.1016/j.yebeh.2003.08.029. View

12.

Paul L, Brown W, Adolphs R, Michael Tyszka J, Richards L, Mukherjee P . Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity. Nat Rev Neurosci. 2007; 8(4):287-99. DOI: 10.1038/nrn2107. View

13.

Gelot A, Lewin F, Moraine C, Pompidou A . [Agenesis of the corpus callosum. Neuropathologic study and physiopathologic hypotheses]. Neurochirurgie. 1998; 44(1 Suppl):74-84. View

14.

Hitosugi T, Tsukamoto M, Ishii K, Kadowaki M, Fujiwara S, Yokoyama T . [Repeated Anesthesia Management in a Patient with Aicardi Syndrome]. Masui. 2016; 65(1):78-81. View

15.

Gertler R, Brown H, Mitchell D, Silvius E . Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent). 2005; 14(1):13-21. PMC: 1291306. DOI: 10.1080/08998280.2001.11927725. View

16.

Bhattacharyya R, Sanyal D, Chakraborty S, Bhattacharyya S . A case of corpus callosum agenesis presenting with recurrent brief depression. Indian J Psychol Med. 2011; 31(2):92-5. PMC: 3168092. DOI: 10.4103/0253-7176.63580. View

17.

Dupre N, Howard H, Mathieu J, Karpati G, Vanasse M, Bouchard J . Hereditary motor and sensory neuropathy with agenesis of the corpus callosum. Ann Neurol. 2003; 54(1):9-18. DOI: 10.1002/ana.77777. View