Prognostic Value of Pretreatment Prognostic Nutritional Index in Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis

Overview

Journal Int J Biol Markers

Specialties Biochemistry
Oncology

Date 2018 Oct 5

PMID 30282502

Citations 41

Authors

Yuanyuan Hu

Jie Shen

Ruike Liu

Zhimei Feng

Changning Zhang

Li Ling

Libo Chen

Affiliations

Soon will be listed here.

Abstract

Background:: The pretreatment prognostic nutritional index has been considered a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC), but this remains controversial. Therefore, we performed a meta-analysis to systematically assess the prognostic value of the prognostic nutritional index in patients with NSCLC.

Methods:: We systematically searched PubMed, EMBASE, Web of Science, and CNKI. The hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were used to evaluate the link between the prognostic nutritional index and the oncological outcomes of patients with NSCLC, including overall survival, disease-free survival/recurrence-free survival, and progression-free survival.

Results:: Fifteen studies were included in this meta-analysis. Twelve of these studies explored the association between the prognostic nutritional index and the overall survival of patients with NSCLC. Our pooled analysis indicated that a low prognostic nutritional index was significantly related to adverse overall survival (HR 1.61; 95% CI 1.44, 1.81; P < 0.001). Our results also showed that the prognostic nutritional index was a negative predictor for disease-free survival/recurrence-free survival, and progression-free survival in patients with NSCLC.

Conclusion:: Our meta-analysis demonstrated that there was a close association between the prognostic nutritional index value and prognosis in NSCLC patients and that the prognostic nutritional index may act as a useful prognostic biomarker in NSCLC patients.

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