Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

Overview

Journal Am J Perinatol

Specialty Gynecology & Obstetrics

Date 2018 Oct 4

PMID 30282103

Citations 4

Authors

Cande V Ananth

Kathleen Jablonski

Leslie Myatt

James M Roberts

Alan T N Tita

Kenneth J Leveno

Uma M Reddy

Michael W Varner

John M Thorp Jr

Brian M Mercer

Alan M Peaceman

Susan M Ramin

Marshall W Carpenter

Philip Samuels

Anthony Sciscione

Jorge E Tolosa

George Saade

Yoram Sorokin

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s).

Study Design: We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions.

Results: Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% ( = 5,374) on all three family members, 26.5% ( = 2,562) in mother and sister(s) only, and 11.6% ( = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption.

Conclusion: This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

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