Conditioned Increase of Locomotor Activity Induced by Haloperidol

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Oct 4

PMID 30281607

Citations 6

Authors

Luis Gonzalo De La Casa

Lucia Carcel

Juan Carlos Ruiz-Salas

Lucia Vicente

Auxiliadora Mena

Affiliations

Soon will be listed here.

Abstract

Dopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol can act as an unconditioned stimulus, we carried out two experiments in which the administration of haloperidol was repeatedly paired with the presence of distinctive contextual cues that served as a Conditioned Stimulus. Paradoxically, the results revealed a dose-dependent increase in locomotor activity following conditioning with dopamine antagonist (Experiments 1) that was susceptible of extinction when the conditioned stimulus was presented repeatedly by itself after conditioning (Experiment 2). These data are interpreted from an associative perspective, considering them as a result of a classical conditioning process.

Citing Articles

Effect of a helium and oxygen mixture on physiological parameters of rats with cerebral arterial air embolism.

Palikov V, Pavlov N, Amirov R, Ismailova A, Borozdina N, Palikova Y Front Physiol. 2024; 15:1388331.

PMID: 38803366 PMC: 11128824. DOI: 10.3389/fphys.2024.1388331.

Intranasal inorganic cerium oxide nanoparticles ameliorate oxidative stress induced motor manifestations in haloperidol-induced parkinsonism.

Mohammad , Khan U, Saifi Z, Bora J, Warsi M, Abourehab M Inflammopharmacology. 2023; 31(5):2571-2585.

PMID: 37432554 DOI: 10.1007/s10787-023-01274-1.

Unconditioned and conditioned anxiolytic effects of Sodium Valproate on flavor neophobia and fear conditioning.

Cintado M, Gonzalez G, Carcel L, De La Casa L PLoS One. 2023; 18(7):e0279511.

PMID: 37418453 PMC: 10328238. DOI: 10.1371/journal.pone.0279511.

Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.

Paraiso I, Mattio L, Magana A, Choi J, Plagmann L, Redick M ACS Pharmacol Transl Sci. 2021; 4(6):1782-1793.

PMID: 34927010 PMC: 8669715. DOI: 10.1021/acsptsci.1c00161.

Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy.

Carcel L, De la Casa L Front Behav Neurosci. 2021; 15:713512.

PMID: 34276319 PMC: 8283013. DOI: 10.3389/fnbeh.2021.713512.

References

Pickens R, CROWDER W . Effects of CS-US interval on conditioning of drug response, with assessment of speed of conditioning. Psychopharmacologia. 1967; 11(1):88-94. DOI: 10.1007/BF00401511. View

Ahmed S, Stinus L, Cador M . Amphetamine-induced conditioned activity is insensitive to perturbations known to affect pavlovian conditioned responses in rats. Behav Neurosci. 1998; 112(5):1167-76. DOI: 10.1037//0735-7044.112.5.1167. View

Schmidt W, Beninger R . Behavioural sensitization in addiction, schizophrenia, Parkinson's disease and dyskinesia. Neurotox Res. 2006; 10(2):161-6. DOI: 10.1007/BF03033244. View

Brudzynski S, Krol S . Analysis of locomotor activity in the rat: parallelism index, a new measure of locomotor exploratory pattern. Physiol Behav. 1997; 62(3):635-42. DOI: 10.1016/s0031-9384(97)00189-3. View

Beninger R, Hahn B . Pimozide blocks establishment but not expression of amphetamine-produced environment-specific conditioning. Science. 1983; 220(4603):1304-6. DOI: 10.1126/science.6857251. View

Dickinson A, Mackintosh N . Classical conditioning in animals. Annu Rev Psychol. 1978; 29:587-612. DOI: 10.1146/annurev.ps.29.020178.003103. View

Barr G, Sharpless N, Cooper S, Schiff S, PAREDES W, BRIDGER W . Classical conditioning, decay and extinction of cocaine-induced hyperactivity and stereotypy. Life Sci. 1983; 33(14):1341-51. DOI: 10.1016/0024-3205(83)90817-2. View

Pavlov P . Conditioned reflexes: An investigation of the physiological activity of the cerebral cortex. Ann Neurosci. 2014; 17(3):136-41. PMC: 4116985. DOI: 10.5214/ans.0972-7531.1017309. View

Eikelboom R, Stewart J . Conditioning of drug-induced physiological responses. Psychol Rev. 1982; 89(5):507-28. View

10.

Geyer M, Russo P, Segal D, Kuczenski R . Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats. Pharmacol Biochem Behav. 1987; 28(3):393-9. DOI: 10.1016/0091-3057(87)90460-6. View

11.

Siegel S . Morphine tolerance acquisition as an associative process. J Exp Psychol Anim Behav Process. 1977; 3(1):1-13. DOI: 10.1037//0097-7403.3.1.1. View

12.

Santos B, Carey R, Carrera M . The acquisition, extinction and spontaneous recovery of Pavlovian drug conditioning induced by post-trial dopaminergic stimulation/inhibition. Pharmacol Biochem Behav. 2017; 156:24-29. DOI: 10.1016/j.pbb.2017.04.002. View

13.

Elias J, Yandell L, Graff R, ALBRECHT J, Smith C . Short term augmentation of amphetamine-induced rotation bias. Physiol Behav. 1983; 31(5):639-42. View

14.

Eikelboom R, Stewart J . Conditioned temperature effects using morphine as the unconditioned stimulus. Psychopharmacology (Berl). 1979; 61(1):31-8. DOI: 10.1007/BF00426807. View

15.

Carey R, Huston J, Muller C . Pharmacological inhibition of dopamine and serotonin activity blocks spontaneous and cocaine-activated behaviour. Prog Brain Res. 2008; 172:347-60. DOI: 10.1016/S0079-6123(08)00917-5. View

16.

Banasikowski T, Beninger R . Haloperidol conditioned catalepsy in rats: a possible role for D1-like receptors. Int J Neuropsychopharmacol. 2011; 15(10):1525-34. DOI: 10.1017/S1461145711001696. View

17.

Furedy J, Poulos C . Heart-rate decelerative Pavlovian conditioning with tilt as UCS: towards behavioural control of cardiac dysfunction. Biol Psychol. 1976; 4(2):93-106. DOI: 10.1016/0301-0511(76)90010-7. View

18.

Mena A, De la Casa L . Prepulse inhibition modulation by contextual conditioning of dopaminergic activity. Behav Brain Res. 2013; 252:188-94. DOI: 10.1016/j.bbr.2013.06.005. View

19.

Ford C . The role of D2-autoreceptors in regulating dopamine neuron activity and transmission. Neuroscience. 2014; 282:13-22. PMC: 4108583. DOI: 10.1016/j.neuroscience.2014.01.025. View

20.

Battisti J, Uretsky N, Wallace L . Importance of environmental context in the development of amphetamine- or apomorphine-induced stereotyped behavior after single and multiple doses. Pharmacol Biochem Behav. 2000; 66(4):671-7. DOI: 10.1016/s0091-3057(00)00214-8. View