Viral Sepsis in Children

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2018 Oct 4

PMID 30280095

Citations 14

Authors

Neha Gupta

Robert Richter

Stephen Robert

Michele Kong

Affiliations

Soon will be listed here.

Abstract

Sepsis in children is typically presumed to be bacterial in origin until proven otherwise, but frequently bacterial cultures ultimately return negative. Although viruses may be important causative agents of culture-negative sepsis worldwide, the incidence, disease burden and mortality of viral-induced sepsis is poorly elucidated. Consideration of viral sepsis is critical as its recognition carries implications on appropriate use of antibacterial agents, infection control measures, and, in some cases, specific, time-sensitive antiviral therapies. This review outlines our current understanding of viral sepsis in children and addresses its epidemiology and pathophysiology, including pathogen-host interaction during active infection. Clinical manifestation, diagnostic testing, and management options unique to viral infections will be outlined.

Citing Articles

Neonatal Sepsis: Aetiology, Pathophysiology, Diagnostic Advances and Management Strategies.

Raturi A, Chandran S Clin Med Insights Pediatr. 2024; 18:11795565241281337.

PMID: 39371316 PMC: 11452898. DOI: 10.1177/11795565241281337.

Profile analysis of emerging respiratory virus in children.

Moreira A, Silva P, do Prado Assuncao L, de Oliveira Santos M, Regina Malveste Ito C, Araujo K Eur J Clin Microbiol Infect Dis. 2023; 42(7):873-882.

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Characterization of T Helper 1 and 2 Cytokine Profiles in Newborns of Mothers with COVID-19.

Moreira A, Silva P, Gomes R, de Oliveira Santos M, Regina Malveste Ito C, Candido Goncalves Barbosa L Biomedicines. 2023; 11(3).

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A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis.

Liu J, Zhao H, Feng Z, Liu Y, Feng Q, Qian S Virol J. 2022; 19(1):72.

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Neutrophil Extracellular Traps in Severe SARS-CoV-2 Infection: A Possible Impact of LPS and (1→3)-β-D-glucan in Blood from Gut Translocation.

Saithong S, Worasilchai N, Saisorn W, Udompornpitak K, Bhunyakarnjanarat T, Chindamporn A Cells. 2022; 11(7).

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