Oral Levetiracetam As Add-On Therapy in Refractory Neonatal Seizures

Overview

Journal Iran J Child Neurol

Specialty Pediatrics

Date 2018 Oct 4

PMID 30279713

Citations 4

Authors

Mohsen Mollamohammadi

Zeinab Sadat Amirhoseini

Alireza Saadati

Zahra Pirzadeh

Masoud Hassan Amouzadeh

Affiliations

Soon will be listed here.

Abstract

Objective: Seizure is the most common signs of nervous system disease in neonates. The first line of treatments in neonatal seizures (after ruling out and emergency treatment of electrolyte imbalance and hypoglycemia) are phenobarbital and phenytoin. We aimed to evaluate drugs that are more effective on neonatal seizure.

Materials & Methods: Patients admitted to neonatal wards & NICUs (level IIa& IIb) in Qom hospitals (2015-2017), central Iran with presentation of seizure, were enrolled in this clinical trial study. After ruling out electrolyte imbalance and hypoglycemia these neonates were managed by intravenous phenobarbital, then if no response was seen we added intravenous phenytoin and for remaining neonates with refractory seizure we applied oral levetiracetam as add on therapy. The study was registered as code number of IRCT2016051527896N1.

Results: Initially, 245 neonates were enrolled. According to exclusion criteria, 12 cases were excluded, and phenobarbital was prescribed to the remaining patients. Out of these, 86 patients did not respond, and phenytoin was prescribed for them. Forty two patients who were not responding to phenytoin were finally treated with oral levetiracetam. Finally, 95.3% of seizures were controlled with oral levetiracetam but 4.7% were not cured.

Conclusion: When the intravenous form of levetiracetam is not available and neonatal seizure does not respond to first line classic drugs, oral levetiracetam as add on therapy maybe effective.

Citing Articles

Anti-seizure medications for neonates with seizures.

Abiramalatha T, Thanigainathan S, Ramaswamy V, Pressler R, Brigo F, Hartmann H Cochrane Database Syst Rev. 2023; 10:CD014967.

PMID: 37873971 PMC: 10594593. DOI: 10.1002/14651858.CD014967.pub2.

Comparing the Efficacy and Safety of Levetiracetam Versus Phenytoin for Treating the Acute Phase of Neonatal Seizures.

Mohammadi M, Kadivar M, Sangsari R, Mirnia K, Saeedi M, Adhami P Iran J Child Neurol. 2023; 17(1):65-71.

PMID: 36721831 PMC: 9881830. DOI: 10.22037/ijcn.v17i1.36008.

Refractory neonatal seizures caused by hemimegalencephaly.

Mohamed K, Elmalik E, Bakry M, Bayoumi M BMJ Case Rep. 2022; 15(9).

PMID: 36104033 PMC: 9476121. DOI: 10.1136/bcr-2022-251587.

Efficacy and Safety of Levetiracetam vs. Phenobarbital for Neonatal Seizures: A Systematic Review and Meta-Analysis.

Qiao M, Cui H, Zhao L, Miao J, Chen Q Front Neurol. 2021; 12:747745.

PMID: 34867732 PMC: 8636327. DOI: 10.3389/fneur.2021.747745.

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