Sex Differences in Associations Among Metabolic Syndrome, Obesity, Related Biomarkers, and Colorectal Adenomatous Polyp Risk in a Japanese Population

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2018 Oct 4

PMID 30279628

Citations 8

Authors

Keisuke Nakai

Jiro Watari

Katsuyuki Tozawa

Akio Tamura

Ken Hara

Takahisa Yamasaki

Takashi Kondo

Tomoaki Kono

Toshihiko Tomita

Yoshio Ohda

Tadayuki Oshima

Hirokazu Fukui

Jun Sakurai

Yongmin Kim

Yuji Hayakawa

Takashi Fujisawa

Takeshi Morimoto

Hiroto Miwa

Affiliations

Soon will be listed here.

Abstract

To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women. Metabolic syndrome was a risk factor for adenomatous polyps in both sexes. Large waist circumference was an independent risk factor for adenomatous polyps in men, and high BMI and large waist circumference were risk factors for adenomatous polyps in women. Interestingly, low BMI was associated with large adenomatous polyps (≥10 mm) and advanced adenoma, and waist-hip ratio was involved in proximal adenomatous polyp development only in women. In contrast, the highest quartile of leptin concentration had a 3.67-fold increased adenomatous polyp risk compared with the lowest quartile only in men. These results indicate that regarding colorectal pathogenesis, sex differences were identified in obesity but not in metabolic syndrome. Visceral obesity and a high serum leptin level may be risk factors for colorectal adenomatous polyp development in Japanese men.

Citing Articles

Risk Factors for Colorectal Adenoma and Cancer in Comprehensive Health Checkups: Usefulness of Gamma-Glutamyltransferase.

Yamanouchi Y, Osawa M, Senbonmatsu T, Shiko Y, Kawasaki Y, Muramatsu T J Pers Med. 2024; 14(11).

PMID: 39590574 PMC: 11595480. DOI: 10.3390/jpm14111082.

Development and validation of a nomogram predictive model for colorectal adenoma with low-grade intraepithelial neoplasia using routine laboratory tests: A single-center case-control study in China.

Wang H, Liu X, Long J, Huang J, Lyu S, Zhao X Heliyon. 2023; 9(11):e20996.

PMID: 38027648 PMC: 10660008. DOI: 10.1016/j.heliyon.2023.e20996.

Serum microRNA Levels as a Biomarker for Diagnosing Non-Alcoholic Fatty Liver Disease in Chinese Colorectal Polyp Patients.

Ng L, Sin R, Cheung D, Leung W, Man A, Lo O Int J Mol Sci. 2023; 24(10).

PMID: 37240431 PMC: 10218925. DOI: 10.3390/ijms24109084.

Factors Associated with Colorectal Polyps in Middle-Aged and Elderly Populations.

Loke S, Chuah S Int J Environ Res Public Health. 2022; 19(12).

PMID: 35742789 PMC: 9223574. DOI: 10.3390/ijerph19127543.

The predictive value of routine laboratory tests for colorectal polyps: a retrospective study.

Feng X, Jiao X, Xu Y, Xu X, Zhu Y, She Q J Gastrointest Oncol. 2022; 13(1):256-264.

PMID: 35284126 PMC: 8899762. DOI: 10.21037/jgo-21-933.

References

Pyo J, Kim E, Chun H, Keum B, Jeen Y, Lee H . Fasting blood sugar and serum triglyceride as the risk factors of colorectal adenoma in korean population receiving screening colonoscopy. Clin Nutr Res. 2013; 2(1):34-41. PMC: 3572815. DOI: 10.7762/cnr.2013.2.1.34. View

Eckel R, Grundy S, Zimmet P . The metabolic syndrome. Lancet. 2005; 365(9468):1415-28. DOI: 10.1016/S0140-6736(05)66378-7. View

Dixon M . Gastrointestinal epithelial neoplasia: Vienna revisited. Gut. 2002; 51(1):130-1. PMC: 1773259. DOI: 10.1136/gut.51.1.130. View

Kumor A, Daniel P, Pietruczuk M, Malecka-Panas E . Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients. Int J Colorectal Dis. 2008; 24(3):275-81. DOI: 10.1007/s00384-008-0605-y. View

Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B . Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A. 2004; 101(8):2476-81. PMC: 356975. DOI: 10.1073/pnas.0308671100. View

Hu N, Chen J, Lin Y, Chang J, Chen Y . Stepwise relationship between components of metabolic syndrome and risk of colorectal adenoma in a Taiwanese population receiving screening colonoscopy. J Formos Med Assoc. 2011; 110(2):100-8. DOI: 10.1016/S0929-6646(11)60016-8. View

Calle E, Rodriguez C, Walker-Thurmond K, Thun M . Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003; 348(17):1625-38. DOI: 10.1056/NEJMoa021423. View

Comstock S, Hortos K, Kovan B, McCaskey S, Pathak D, Fenton J . Adipokines and obesity are associated with colorectal polyps in adult males: a cross-sectional study. PLoS One. 2014; 9(1):e85939. PMC: 3895019. DOI: 10.1371/journal.pone.0085939. View

Alberti K, Zimmet P, Shaw J . Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006; 23(5):469-80. DOI: 10.1111/j.1464-5491.2006.01858.x. View

10.

Mitsuhashi K, Hashimoto Y, Tanaka M, Toda H, Matsumoto S, Ushigome E . Combined effect of body mass index and waist-height ratio on incident diabetes; a population based cohort study. J Clin Biochem Nutr. 2017; 61(2):118-122. PMC: 5612813. DOI: 10.3164/jcbn.16-116. View

11.

Lyon C, Law R, Hsueh W . Minireview: adiposity, inflammation, and atherogenesis. Endocrinology. 2003; 144(6):2195-200. DOI: 10.1210/en.2003-0285. View

12.

Chiu H, Lin J, Shun C, Liang J, Lee Y, Huang S . Association of metabolic syndrome with proximal and synchronous colorectal neoplasm. Clin Gastroenterol Hepatol. 2006; 5(2):221-9. DOI: 10.1016/j.cgh.2006.06.022. View

13.

Oda E, Watanabe K . Japanese criteria of metabolic syndrome. Circ J. 2006; 70(3):364. DOI: 10.1253/circj.70.364. View

14.

Kim B, Shin A, Hong C, Sohn D, Han K, Ryu K . Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control. 2012; 23(5):727-35. DOI: 10.1007/s10552-012-9942-9. View

15.

Omata F, Brown W, Tokuda Y, Takahashi O, Fukui T, Ueno F . Modifiable risk factors for colorectal neoplasms and hyperplastic polyps. Intern Med. 2009; 48(3):123-8. DOI: 10.2169/internalmedicine.48.1562. View

16.

Carr D, Utzschneider K, Hull R, Kodama K, Retzlaff B, Brunzell J . Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 2004; 53(8):2087-94. DOI: 10.2337/diabetes.53.8.2087. View

17.

Xu X, Xu Q, Tong J, Zhu M, Huang M, Ran Z . Meta-analysis: circulating adiponectin levels and risk of colorectal cancer and adenoma. J Dig Dis. 2011; 12(4):234-44. DOI: 10.1111/j.1751-2980.2011.00504.x. View

18.

Nam S, Kim B, Han K, Ryu K, Park B, Kim H . Abdominal visceral adipose tissue predicts risk of colorectal adenoma in both sexes. Clin Gastroenterol Hepatol. 2010; 8(5):443-50.e1-2. DOI: 10.1016/j.cgh.2010.02.001. View

19.

Wang Y, Lin S, Lai W, Liu P, Sheu W . Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol. 2005; 20(9):1410-5. DOI: 10.1111/j.1440-1746.2005.03971.x. View

20.

Despres J, Lemieux I . Abdominal obesity and metabolic syndrome. Nature. 2006; 444(7121):881-7. DOI: 10.1038/nature05488. View