Increased Oxidative Stress and Coenzyme Q10 Deficiency in Centenarians

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2018 Oct 4

PMID 30279624

Citations 13

Authors

Midori Nagase

Yorihiro Yamamoto

Nozomi Matsumoto

Yasumichi Arai

Nobuyoshi Hirose

Affiliations

Soon will be listed here.

Abstract

Aging populations are expanding worldwide, and the increasing requirement for nursing care has become a serious problem. Furthermore, successful aging is one of the highest priorities for individuals and societies. Centenarians are an informative cohort to study and inflammation has been found to be a key factor in predicting cognition and physical capabilities. Inflammation scores have been determined based on the levels of cytokines and C-reactive protein, however, serum antioxidants and lipid profiles have not been carefully examined. We found that the redox balance of coenzyme Q10 significantly shifted to the oxidized form and levels of strong antioxidants, such as ascorbic acid and unconjugated bilirubin, decreased significantly compared to 76-year-old controls, indicating an increased oxidative stress in centenarians. Levels of uric acid, an endogenous peroxynitrite scavenger, remained unchanged, suggesting that centenarians were experiencing moderate, chronic inflammatory conditions. Centenarians exhibited a hypocholesterolemic condition, while an increase in the ratio of free cholesterol to cholesterol esters suggests some impairment of liver function. Serum free fatty acids and monoenoic acid composition, markers of tissue oxidative damage, were significantly decreased in centenarians, indicating an impairment in the tissue repair system. Despite an elevation of the coenzyme Q10 binding protein Psap, serum total coenzyme Q10 levels decreased in centenarians. This suggests a serious deficiency of coenzyme Q10 in tissues, since tissue levels of coenzyme Q10 significantly decrease with age. Therefore, coenzyme Q10 supplementation could be beneficial for centenarians.

Citing Articles

Oxidative stress and regulation of adipogenic differentiation capacity by sirtuins in adipose stem cells derived from female patients of advancing age.

Bernhardt A, Jamil A, Morshed M, Ponnath P, Gille V, Stephan N Sci Rep. 2024; 14(1):19885.

PMID: 39191852 PMC: 11349916. DOI: 10.1038/s41598-024-70382-x.

Prosaposin is a novel coenzyme Q10-binding protein.

Hasegawa M, Yamamoto Y, Fujisawa A, Kashiba M J Clin Biochem Nutr. 2024; 74(2):108-112.

PMID: 38510690 PMC: 10948348. DOI: 10.3164/jcbn.23-57.

Study of Diet Habits and Cognitive Function in the Chinese Middle-Aged and Elderly Population: The Association between Folic Acid, B Vitamins, Vitamin D, Coenzyme Q10 Supplementation and Cognitive Ability.

Jiang X, Guo Y, Cui L, Huang L, Guo Q, Huang G Nutrients. 2023; 15(5).

PMID: 36904242 PMC: 10005055. DOI: 10.3390/nu15051243.

Assessing Cellular Uptake of Exogenous Coenzyme Q into Human Skin Cells by X-ray Fluorescence Imaging.

Staufer T, Schulze M, Schmutzler O, Kornig C, Welge V, Burkhardt T Antioxidants (Basel). 2022; 11(8).

PMID: 36009252 PMC: 9405069. DOI: 10.3390/antiox11081532.

Coenzyme Q10 effects in neurological diseases.

Rauchova H Physiol Res. 2022; 70(Suppl4):S683-S714.

PMID: 35199552 PMC: 9054193. DOI: 10.33549/physiolres.934712.

References

Yamagishi K, Ikeda A, Moriyama Y, Chei C, Noda H, Umesawa M . Serum coenzyme Q10 and risk of disabling dementia: the Circulatory Risk in Communities Study (CIRCS). Atherosclerosis. 2014; 237(2):400-3. DOI: 10.1016/j.atherosclerosis.2014.09.017. View

Arai Y, Martin-Ruiz C, Takayama M, Abe Y, Takebayashi T, Koyasu S . Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians. EBioMedicine. 2015; 2(10):1549-58. PMC: 4634197. DOI: 10.1016/j.ebiom.2015.07.029. View

Kashiba M, Terashima M, Sagawa T, Yoshimura S, Yamamoto Y . Prosaposin knockdown in Caco-2 cells decreases cellular levels of coenzyme Q10 and ATP, and results in the loss of tight junction barriers. J Clin Biochem Nutr. 2017; 60(2):81-85. PMC: 5370525. DOI: 10.3164/jcbn.16-32. View

Yasuda M, Fujita T . Effect of lipid peroxidation on phospholipase A2 activity of rat liver mitochondria. Jpn J Pharmacol. 1977; 27(3):429-35. DOI: 10.1254/jjp.27.429. View

Nagase M, Sakurai A, Sugita A, Matsumoto N, Kubo A, Miyazaki Y . Oxidative stress and abnormal cholesterol metabolism in patients with post-cardiac arrest syndrome. J Clin Biochem Nutr. 2017; 61(2):108-117. PMC: 5612819. DOI: 10.3164/jcbn.17-30. View

Santos C, Anjos E, Augusto O . Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation. Arch Biochem Biophys. 1999; 372(2):285-94. DOI: 10.1006/abbi.1999.1491. View

Arai Y, Sasaki T, Hirose N . Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Honshu, Japan: Part 2 Honshu, Japan. Mech Ageing Dev. 2017; 165(Pt B):80-85. DOI: 10.1016/j.mad.2017.02.005. View

Hara K, Yamashita S, Fujisawa A, Ishiwa S, Ogawa T, Yamamoto Y . Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids. Biochem Biophys Res Commun. 1999; 257(1):244-8. DOI: 10.1006/bbrc.1999.0436. View

Yamamoto Y, Yanagisawa M, Tak N, Watanabe K, Takahashi C, Fujisawa A . Repeated edaravone treatment reduces oxidative cell damage in rat brain induced by middle cerebral artery occlusion. Redox Rep. 2009; 14(6):251-8. DOI: 10.1179/135100009X12525712409779. View

10.

Scott G, Cuzzocrea S, Genovese T, Koprowski H, Hooper D . Uric acid protects against secondary damage after spinal cord injury. Proc Natl Acad Sci U S A. 2005; 102(9):3483-8. PMC: 552934. DOI: 10.1073/pnas.0500307102. View

11.

Stocker R, Yamamoto Y, McDonagh A, Glazer A, Ames B . Bilirubin is an antioxidant of possible physiological importance. Science. 1987; 235(4792):1043-6. DOI: 10.1126/science.3029864. View

12.

Nagase M, Yamamoto Y, Miyazaki Y, Yoshino H . Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration. Redox Rep. 2015; 21(3):104-12. PMC: 6837462. DOI: 10.1179/1351000215Y.0000000026. View

13.

. Mutations in COQ2 in familial and sporadic multiple-system atrophy. N Engl J Med. 2013; 369(3):233-44. DOI: 10.1056/NEJMoa1212115. View

14.

Mitsui J, Tsuji S . Plasma Coenzyme Q10 Levels and Multiple System Atrophy-Reply. JAMA Neurol. 2016; 73(12):1499-1500. DOI: 10.1001/jamaneurol.2016.4133. View

15.

Jin G, Kubo H, Kashiba M, Horinouchi R, Hasegawa M, Suzuki M . Saposin B is a human coenzyme q10-binding/transfer protein. J Clin Biochem Nutr. 2008; 42(2):167-74. PMC: 2266064. DOI: 10.3164/jcbn.2008024. View

16.

Wada H, Goto H, Hagiwara S, Yamamoto Y . Redox status of coenzyme Q10 is associated with chronological age. J Am Geriatr Soc. 2007; 55(7):1141-2. DOI: 10.1111/j.1532-5415.2007.01209.x. View

17.

Ntambi J . Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res. 1999; 40(9):1549-58. View

18.

Weglicki W, Dickens B, Mak I . Enhanced lysosomal phospholipid degradation and lysophospholipid production due to free radicals. Biochem Biophys Res Commun. 1984; 124(1):229-35. DOI: 10.1016/0006-291x(84)90941-0. View

19.

Tsukada K, Hasegawa T, Tsutsumi S, Katoh H, Kuwano H, Miyazaki T . Effect of uric acid on liver injury during hemorrhagic shock. Surgery. 2000; 127(4):439-46. DOI: 10.1067/msy.2000.104486. View

20.

Yamamoto Y, Yamashita S, Fujisawa A, Kokura S, Yoshikawa T . Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants. Biochem Biophys Res Commun. 1998; 247(1):166-70. DOI: 10.1006/bbrc.1998.8752. View