Enteric Fever Cases in the Two Largest Pediatric Hospitals of Bangladesh: 2013-2014

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2018 Oct 3

PMID 30277511

Citations 6

Authors

Shampa Saha

Mohammad J Uddin

Maksuda Islam

Rajib C Das

Denise Garrett

Samir Kumar Saha

Affiliations

Soon will be listed here.

Abstract

Background: Enteric fever predominantly affects children in low- and middle-income countries. This study examines the burden of enteric fever at the 2 pediatric hospitals in Dhaka, Bangladesh and assesses their capacity for inclusion in a prospective cohort study to support enteric fever prevention and control.

Methods: A descriptive study of enteric fever was conducted among children admitted in 2013-2014 to inpatient departments of Dhaka Shishu and Shishu Shashthya Foundation Hospitals, sentinel hospitals of the World Health Organization-supported Invasive Bacterial Vaccine Preventable Disease surveillance platform.

Results: Of 15917 children with blood specimens received by laboratories, 2.8% (443 of 15917) were culture positive for significant bacterial growth. Sixty-three percent (279 of 443) of these isolates were confirmed as the cases of enteric fever (241 Salmonella Typhi and 38 Salmonella Paratyphi A). In addition, 1591 children had suspected enteric fever. Overall, 3.6% (1870 of 51923) were laboratory confirmed or suspected enteric fever cases (55% male, median age 2 years, 86% from Dhaka district, median hospital stay 5 days).

Conclusions: The burden of enteric fever among inpatients at 2 pediatric hospitals in Dhaka, Bangladesh is substantial. Therefore, inclusion of these hospitals in a prospective cohort study will be useful for the generation of credible disease burden estimates of enteric fever in Bangladesh.

Citing Articles

Clinical and Laboratory Features of Enteric Fever in Children and Antibiotic Sensitivity Pattern in a Tertiary Care Hospital of a Low- and Middle-Income Country.

Nusrat N, Islam M, Paul N, Rahman N, Krishnapillai A, Haq M Cureus. 2022; 14(10):e30784.

PMID: 36320797 PMC: 9614183. DOI: 10.7759/cureus.30784.

Acute febrile illness among outpatients seeking health care in Bangladeshi hospitals prior to the COVID-19 pandemic.

Das P, Ziaur Rahman M, Banu S, Rahman M, Chisti M, Chowdhury F PLoS One. 2022; 17(9):e0273902.

PMID: 36048788 PMC: 9436081. DOI: 10.1371/journal.pone.0273902.

Hospitalization of Pediatric Enteric Fever Cases, Dhaka, Bangladesh, 2017-2019: Incidence and Risk Factors.

Saha S, Sayeed K, Saha S, Islam M, Rahaman A, Islam M Clin Infect Dis. 2020; 71(Suppl 3):S196-S204.

PMID: 33258942 PMC: 7705877. DOI: 10.1093/cid/ciaa1356.

Utilization of Blood Culture in South Asia for the Diagnosis and Treatment of Febrile Illness.

Hemlock C, Luby S, Saha S, Qamar F, Andrews J, Saha S Clin Infect Dis. 2020; 71(Suppl 3):S266-S275.

PMID: 33258939 PMC: 7705874. DOI: 10.1093/cid/ciaa1322.

Phase I of the Surveillance for Enteric Fever in Asia Project (SEAP): An Overview and Lessons Learned.

Barkume C, Date K, Saha S, Qamar F, Sur D, Andrews J J Infect Dis. 2018; 218(suppl_4):S188-S194.

PMID: 30304505 PMC: 6226726. DOI: 10.1093/infdis/jiy522.

References

Dewan A, Corner R, Hashizume M, Ongee E . Typhoid Fever and its association with environmental factors in the Dhaka Metropolitan Area of Bangladesh: a spatial and time-series approach. PLoS Negl Trop Dis. 2013; 7(1):e1998. PMC: 3554574. DOI: 10.1371/journal.pntd.0001998. View

Steele A, Hay Burgess D, Diaz Z, Carey M, Zaidi A . Challenges and Opportunities for Typhoid Fever Control: A Call for Coordinated Action. Clin Infect Dis. 2016; 62 Suppl 1:S4-8. PMC: 4772836. DOI: 10.1093/cid/civ976. View

Saha S, Islam M, Uddin M, Saha S, Das R, Baqui A . Integration of enteric fever surveillance into the WHO-coordinated Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) platform: A low cost approach to track an increasingly important disease. PLoS Negl Trop Dis. 2017; 11(10):e0005999. PMC: 5658195. DOI: 10.1371/journal.pntd.0005999. View

Darton T, Meiring J, Tonks S, Khan M, Khanam F, Shakya M . The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys. BMJ Open. 2017; 7(6):e016283. PMC: 5726077. DOI: 10.1136/bmjopen-2017-016283. View

Ahmed D, Nahid M, Sami A, Halim F, Akter N, Sadique T . Bacterial etiology of bloodstream infections and antimicrobial resistance in Dhaka, Bangladesh, 2005-2014. Antimicrob Resist Infect Control. 2017; 6:2. PMC: 5217397. DOI: 10.1186/s13756-016-0162-z. View

Maude R, Ghose A, Samad R, de Jong H, Fukushima M, Wijedoru L . A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh. BMC Infect Dis. 2016; 16(1):567. PMC: 5064917. DOI: 10.1186/s12879-016-1886-3. View

Crump J, Ram P, Gupta S, Miller M, Mintz E . Part I. Analysis of data gaps pertaining to Salmonella enterica serotype Typhi infections in low and medium human development index countries, 1984-2005. Epidemiol Infect. 2007; 136(4):436-48. PMC: 2870843. DOI: 10.1017/S0950268807009338. View

Naheed A, Ram P, Brooks W, Hossain M, Parsons M, Talukder K . Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh. Int J Infect Dis. 2010; 14 Suppl 3:e93-9. DOI: 10.1016/j.ijid.2009.11.023. View

Akullian A, Ngeno E, Matheson A, Cosmas L, Macharia D, Fields B . Environmental Transmission of Typhoid Fever in an Urban Slum. PLoS Negl Trop Dis. 2015; 9(12):e0004212. PMC: 4669139. DOI: 10.1371/journal.pntd.0004212. View

10.

. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1545-1602. PMC: 5055577. DOI: 10.1016/S0140-6736(16)31678-6. View

11.

Kariuki S, Gordon M, Feasey N, Parry C . Antimicrobial resistance and management of invasive Salmonella disease. Vaccine. 2015; 33 Suppl 3:C21-9. PMC: 4469558. DOI: 10.1016/j.vaccine.2015.03.102. View

12.

Saha S, Naheed A, El Arifeen S, Islam M, Al-Emran H, Amin R . Surveillance for invasive Streptococcus pneumoniae disease among hospitalized children in Bangladesh: antimicrobial susceptibility and serotype distribution. Clin Infect Dis. 2009; 48 Suppl 2:S75-81. DOI: 10.1086/596544. View

13.

Date K, Newton A, Medalla F, Blackstock A, Richardson L, McCullough A . Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008-2012. Clin Infect Dis. 2016; 63(3):322-9. PMC: 5207092. DOI: 10.1093/cid/ciw232. View

14.

. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1459-1544. PMC: 5388903. DOI: 10.1016/S0140-6736(16)31012-1. View

15.

Saha S, Baqui A, Hanif M, Darmstadt G, Ruhulamin M, Nagatake T . Typhoid fever in Bangladesh: implications for vaccination policy. Pediatr Infect Dis J. 2001; 20(5):521-4. DOI: 10.1097/00006454-200105000-00010. View

16.

Brooks W, Hossain A, Goswami D, Nahar K, Alam K, Ahmed N . Bacteremic typhoid fever in children in an urban slum, Bangladesh. Emerg Infect Dis. 2005; 11(2):326-9. PMC: 3320465. DOI: 10.3201/eid1102.040422. View

17.

Luby S, Saha S, Andrews J . Towards sustainable public health surveillance for enteric fever. Vaccine. 2015; 33 Suppl 3:C3-7. DOI: 10.1016/j.vaccine.2015.02.054. View

18.

Azmatullah A, Qamar F, Thaver D, Zaidi A, Bhutta Z . Systematic review of the global epidemiology, clinical and laboratory profile of enteric fever. J Glob Health. 2015; 5(2):020407. PMC: 4672836. DOI: 10.7189/jogh.05.020407. View