Enhanced Expression of Nidogen 1 Around the Nest of Basal Cell Carcinoma Compared with That Around Squamous Cell Carcinoma

Overview

Journal Med Mol Morphol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Pathology

Date 2018 Oct 3

PMID 30276677

Citations 3

Authors

Y Hirakawa

S Futaki

H Tanizaki

F Furukawa

K Maemura

Y Kondo

S Moriwaki

Affiliations

Soon will be listed here.

Abstract

Basal cell carcinoma (BCC) is a malignant skin tumor originating from cells of the epidermal basal layer and adnexal epithelium, especially in sun-exposed areas. Unlike squamous cell carcinoma (SCC), BCC has a propensity to grow only locally possibly due to differences in the surrounding microenvironment including the basement membrane (BM) and stroma. To investigate the components constituting the BM and surrounding connective tissue in BCC and SCC, we analyzed the expression of BM proteins, nidogen 1 (NID1) and type IV collagen (COL4). We compared the immunohistochemical expressions of NID1 and COL4 among tumor specimens from BCC, SCC and its precancerous condition, actinic keratosis (AK), (n = 5 each condition). The expressions of NID1 and COL4 were both decreased around the tumor nest of SCC. In contrast, the expressions of both NID1 and COL4 around the nest of BCC were much higher than in the peri-lesional normal skin not only at the BM, but also in the surrounding stromal tissue. Our findings imply that the surrounding stromal cells of BCC, but not SCC or AK, excessively produce NID1 and COL4, which may be involved in preventing BCC cells from destroying the BM and invading the dermis.

Citing Articles

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Collagen Remodeling along Cancer Progression Providing a Novel Opportunity for Cancer Diagnosis and Treatment.

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Matrix Effectors in the Pathogenesis of Keratinocyte-Derived Carcinomas.

Kavasi R, Neagu M, Constantin C, Munteanu A, Surcel M, Tsatsakis A Front Med (Lausanne). 2022; 9:879500.

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