Significant Association of Long Non-coding RNAs HOTAIR Genetic Polymorphisms with Cancer Recurrence and Patient Survival in Patients with Uterine Cervical Cancer

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2018 Oct 3

PMID 30275757

Citations 21

Authors

Shun-Long Weng

Wen-Jun Wu

Yi-Hsuan Hsiao

Shun-Fa Yang

Chun-Fang Hsu

Po-Hui Wang

Affiliations

Soon will be listed here.

Abstract

Up to date, no study explores the relationship of single nucleotide polymorphisms (SNPs) of long non-coding RNAs HOTAIR (lncRNAs HOTAIR) with cancer recurrence and patient survival in uterine cervical cancer for Taiwanese women. We therefore designed this study to investigate the clinical roles of lncRNAs HOTAIR SNPs in cervical cancer. One hundred and sixteen patients with cervical invasive cancer and 96 patients with preinvasive lesions as well as 318 control women were consecutively recruited. LncRNAs HOTAIR SNPs rs920778, rs12427129, rs4759314 and rs1899663 were analyzed and their genotypic frequencies were examined by real-time polymerase chain reaction. The results indicated that there were no genotypic differences between patients with cervical neoplasia and normal controls as well as among patients with invasive and invasive cancer, and normal controls. However, genotype GG in lncRNAs HOTAIR SNP rs920778 was demonstrated to be a predictor for poorer cancer recurrence probability [=0.001, hazard ratio (HR): 7.25, 95% CI: 2.19-23.96]. Furthermore, cervical cancer patients with genotype GG in lncRNAs HOTAIR rs920778 had worse overall survival ( 0.002, HR: 7.22, 95% CI: 2.09-24.92). No significant associations exhibited between lncRNAs HOTAIR SNP rs920778 and clinicopathological parameters. In conclusion, this studied lncRNAs HOTAIR SNPs are not associated with cervical carcinongensis. However, lncRNAs HOTAIR SNP rs920778 may be regarded as an independent predictor of cancer recurrence probability and overall survival in cervical cancer patients.

Citing Articles

HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives.

Nazari M, Babakhanzadeh E, Mollazadeh A, Ahmadzade M, Mohammadi Soleimani E, Hajimaqsoudi E Cancer Cell Int. 2024; 24(1):415.

PMID: 39702144 PMC: 11660992. DOI: 10.1186/s12935-024-03612-x.

Comprehensive investigation of long non-coding RNA HOTAIR polymorphisms and cancer risk: a current meta-analysis encompassing 96,458 participants.

Krishna B, Garg P, Ramisetty S, Subbalakshmi A, Kulkarni P, Salgia R Sci Rep. 2024; 14(1):22670.

PMID: 39349529 PMC: 11442654. DOI: 10.1038/s41598-024-72586-7.

HOTAIR Promotes the Hyperactivation of PI3K/Akt and Wnt/β-Catenin Signaling Pathways via PTEN Hypermethylation in Cervical Cancer.

Trujano-Camacho S, Leon D, Perez-Yepez E, Contreras-Romero C, Coronel-Hernandez J, Millan-Catalan O Cells. 2024; 13(17.

PMID: 39273054 PMC: 11394386. DOI: 10.3390/cells13171484.

Role of rs2366152 single-nucleotide variant located in the long noncoding RNA HOTAIR gene in the cervical cancer susceptibility in a Polish population.

Lazniak S, Sowinska A, Roszak A, Lianeri M, Plawski A, Mostowska A J Appl Genet. 2023; 65(3):511-518.

PMID: 38157198 PMC: 11310296. DOI: 10.1007/s13353-023-00822-3.

Impact of genetic variants on uterine cervical cancer clinicopathologic characteristics.

Sun Y, Chen L, Wang C, Lee C, Hsiao Y, Yang S J Cancer. 2023; 14(13):2529-2537.

PMID: 37670967 PMC: 10475370. DOI: 10.7150/jca.86678.

References

Bharti A, Shukla S, Mahata S, Hedau S, Das B . Anti-human papillomavirus therapeutics: facts & future. Indian J Med Res. 2009; 130(3):296-310. View

Kim H, Lee D, Yim G, Nam E, Kim S, Kim S . Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int J Oncol. 2014; 46(2):521-30. PMC: 4277242. DOI: 10.3892/ijo.2014.2758. View

Wu Z, Wang X, Tang H, Jiang T, Chen J, Lu S . Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer. Oncol Rep. 2014; 32(1):395-402. DOI: 10.3892/or.2014.3186. View

Zhang J, Liu X, You L, Zhou R . Significant association between long non-coding RNA HOTAIR polymorphisms and cancer susceptibility: a meta-analysis. Onco Targets Ther. 2016; 9:3335-43. PMC: 4898434. DOI: 10.2147/OTT.S107190. View

Zhao W, An Y, Liang Y, Xie X . Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer. Eur Rev Med Pharmacol Sci. 2014; 18(13):1930-6. View

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H . The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 2012; 22(9):1775-89. PMC: 3431493. DOI: 10.1101/gr.132159.111. View

Baak J, Kruse A, Robboy S, Janssen E, van Diermen B, Skaland I . Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers. J Clin Pathol. 2006; 59(10):1017-28. PMC: 1861745. DOI: 10.1136/jcp.2005.027839. View

Zhang X, Zhou L, Fu G, Sun F, Shi J, Wei J . The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer. Carcinogenesis. 2014; 35(9):2062-7. DOI: 10.1093/carcin/bgu103. View

Gibb E, Brown C, Lam W . The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011; 10:38. PMC: 3098824. DOI: 10.1186/1476-4598-10-38. View

10.

Chu H, Chen Y, Yuan Q, Hua Q, Zhang X, Wang M . The HOTAIR, PRNCR1 and POLR2E polymorphisms are associated with cancer risk: a meta-analysis. Oncotarget. 2017; 8(26):43271-43283. PMC: 5522144. DOI: 10.18632/oncotarget.14920. View

11.

Wu H, Liu Y, Yang S, Lin W, Chen S, Han C . Association of single-nucleotide polymorphisms of high-mobility group box 1 with susceptibility and clinicopathological characteristics of uterine cervical neoplasia in Taiwanese women. Tumour Biol. 2016; 37:15813–15823. DOI: 10.1007/s13277-016-5408-0. View

12.

Lee M, Kim H, Kim S, Park S, Chun K, Cho N . The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway. Oncotarget. 2016; 7(28):44558-44571. PMC: 5190118. DOI: 10.18632/oncotarget.10065. View

13.

Su S, Reiter R, Hsiao H, Chung W, Yang S . Functional Interaction between Melatonin Signaling and Noncoding RNAs. Trends Endocrinol Metab. 2018; 29(6):435-445. DOI: 10.1016/j.tem.2018.03.008. View

14.

Guo L, Lu X, Zheng L, Liu X, Hu M . Association of Long Non-Coding RNA HOTAIR Polymorphisms with Cervical Cancer Risk in a Chinese Population. PLoS One. 2016; 11(7):e0160039. PMC: 4965140. DOI: 10.1371/journal.pone.0160039. View

15.

Liu S, Zhang M, Qu P . Expression level and clinical significance of HOX transcript antisense intergenic RNA in cervical cancer: a meta-analysis. Sci Rep. 2016; 6:38047. PMC: 5126667. DOI: 10.1038/srep38047. View

16.

Shastry B . SNPs: impact on gene function and phenotype. Methods Mol Biol. 2009; 578:3-22. DOI: 10.1007/978-1-60327-411-1_1. View

17.

Bayram S, Sumbul A, Batmaci C, Genc A . Effect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish population. Tumour Biol. 2015; 36(5):3863-70. DOI: 10.1007/s13277-014-3028-0. View

18.

Su S, Hsieh M, Lin C, Chuang C, Liu Y, Yeh C . Impact of HOTAIR Gene Polymorphism and Environmental Risk on Oral Cancer. J Dent Res. 2018; 97(6):717-724. DOI: 10.1177/0022034517749451. View

19.

Huang L, Liao L, Liu A, Wu J, Cheng X, Lin J . Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. Arch Gynecol Obstet. 2014; 290(4):717-23. DOI: 10.1007/s00404-014-3236-2. View

20.

Pan W, Liu L, Wei J, Ge Y, Zhang J, Chen H . A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility. Mol Carcinog. 2015; 55(1):90-6. DOI: 10.1002/mc.22261. View