Hepatoprotective Effect of Loquat Leaf Flavonoids in PM-Induced Non-Alcoholic Fatty Liver Disease Via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Oct 3

PMID 30275422

Citations 12

Authors

Tunyu Jian

Xiaoqin Ding

Yuexian Wu

Bingru Ren

Weilin Li

Han Lv

Jian Chen

Affiliations

Soon will be listed here.

Abstract

Ambient air particulate matter (PM) represents a class of heterogeneous substances present in polluted air, which contains many harmful components. Exposure to ambient particulate matter in fine rages (PM) is associated with non-alcoholic fatty liver disease (NAFLD). Loquat Leaf possesses pharmacological actions on NAFLD. As the main biological active ingredients, the potential therapeutic role of total flavonoids (TF) isolated from Loquat Leaf in PM-induced NAFLD model remains unclear. The present study was designed to explore the hepatoprotective effect of TF in PM-induced NAFLD mice with its related mechanisms of action. Mice were exposed to PM to induce NAFLD, and body weight, the ratio of liver to body weight, and blood lipids increased significantly compared with the control group. It was found that TF significantly reduced the above parameters in PM-induced NAFLD mice. TF treatment alleviated oxidative stress by preventing the accumulation of oxidative product malondialdehyde (MDA) and by strengthening the anti-oxidative capacity of superoxide dismutase (SOD). TF was also found to reduce the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity in the PM group. In addition, TF repaired the PM-induced decline of insulin receptor substrate-1 (IRs-1) and protein kinase B (Akt) phosphorylation. Meanwhile, the data showed TF suppressed the expression of cytochrome P450 2E1(CYP2E1) and the phosphorylation of c-jun N-terminal kinase (JNK) in PM-induced NAFLD. Taken together, these findings show that TF alleviate PM-induced NAFLD via regulation of IRs-1/Akt and CYP2E1/JNK pathways, which may have potential for further development as novel therapeutic agents for NAFLD.

Citing Articles

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