Effect of Different Sizes of Bioactive Glass-coated Mesoporous Silica Nanoparticles on Dentinal Tubule Occlusion and Mineralization

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2018 Oct 1

PMID 30269174

Citations 19

Authors

Jae-Hyun Jung

Soo-Byung Park

Kyung-Hyeon Yoo

Seog-Young Yoon

Moon-Kyoung Bae

Dong Joon Lee

Ching-Chang Ko

Yong Hoon Kwon

Yong-Il Kim

Affiliations

Soon will be listed here.

Abstract

Objectives: To synthesize two different sizes of bioactive glass-coated mesoporous silica nanoparticles (BGN@MSNs) and to investigate their effects on dentinal tubule occlusion and remineralization.

Materials And Methods: Two different sizes of mesoporous silica nanoparticles (MSNs) were synthesized using the Stöber method (368A, 1840A) and coated with bioactive glass nanoparticles (BGNs) using a modified quick alkali-mediated sol-gel method (368B, 1840B). Sensitive tooth disc models were prepared and divided into six groups and the following treatments were applied: group 1-no treatment, group 2-bioglass, group 3-368A, group 4-368B, group 5-1840A, and group 6-1840B. Then, five discs were selected from each group and soaked in 6 wt% citric acid to test acid resistance. Dentinal tubule occlusion and occlusion ratio were observed using field-emission scanning electron microscopy. In vitro mineralization tests using simulated body fluid solution were performed to evaluate the remineralization effect of the treatment.

Results: All samples effectively occluded the dentinal tubule and formed a membrane-like layer. After acid treatment, 1840B (group 6) exhibited the highest rate of dentinal tubule occlusion. Remineralization was observed in 368B and 1840B, and 1840B exhibited the fastest remineralization.

Conclusions: Dentinal tubule remineralization induced by the BGN@MSN biocomposite can be used to stabilize long-term prognosis in dentin hypersensitivity. The 1840B induced the most efficient remineralization, and its smaller size and larger surface area were effective for remineralization.

Clinical Relevance: The BGN@MSN biocomposite with its smaller size and larger surface area was more effective for remineralization and dentinal tubule sealing.

Citing Articles

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Gelatin-Modified Bioactive Glass for Treatment of Dentin Hypersensitivity.

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Enhancing the inhibition of dental erosion and abrasion with quercetin-encapsulated hollow mesoporous silica nanocomposites.

Chen J, Cheng Y, Yang M, Su C, Yu H Front Bioeng Biotechnol. 2024; 12:1343329.

PMID: 38405377 PMC: 10885352. DOI: 10.3389/fbioe.2024.1343329.

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