Functional and Neuroanatomical Bases of Developmental Stuttering: Current Insights

Overview

Journal Neuroscientist

Publisher Sage Publications

Specialty Neurology

Date 2018 Sep 29

PMID 30264661

Citations 31

Authors

Soo-Eun Chang

Emily O Garnett

Andrew Etchell

Ho Ming Chow

Affiliations

Soon will be listed here.

Abstract

Affecting 5% of all preschool-aged children and 1% of the general population, developmental stuttering-also called childhood-onset fluency disorder-is a complex, multifactorial neurodevelopmental disorder characterized by frequent disruption of the fluent flow of speech. Over the past two decades, neuroimaging studies of both children and adults who stutter have begun to provide significant insights into the neurobiological bases of stuttering. This review highlights convergent findings from this body of literature with a focus on functional and structural neuroimaging results that are supported by theoretically driven neurocomputational models of speech production. Updated views on possible mechanisms of stuttering onset and persistence, and perspectives on promising areas for future research into the mechanisms of stuttering, are discussed.

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References

Smith A, Weber C . How Stuttering Develops: The Multifactorial Dynamic Pathways Theory. J Speech Lang Hear Res. 2017; 60(9):2483-2505. PMC: 5831617. DOI: 10.1044/2017_JSLHR-S-16-0343. View

Bohland J, Guenther F . An fMRI investigation of syllable sequence production. Neuroimage. 2006; 32(2):821-41. DOI: 10.1016/j.neuroimage.2006.04.173. View

Neef N, Hoang T, Neef A, Paulus W, Sommer M . Speech dynamics are coded in the left motor cortex in fluent speakers but not in adults who stutter. Brain. 2015; 138(Pt 3):712-25. PMC: 4408433. DOI: 10.1093/brain/awu390. View

Civier O, Bullock D, Max L, Guenther F . Computational modeling of stuttering caused by impairments in a basal ganglia thalamo-cortical circuit involved in syllable selection and initiation. Brain Lang. 2013; 126(3):263-78. PMC: 3775364. DOI: 10.1016/j.bandl.2013.05.016. View

Cykowski M, Fox P, Ingham R, Ingham J, Robin D . A study of the reproducibility and etiology of diffusion anisotropy differences in developmental stuttering: a potential role for impaired myelination. Neuroimage. 2010; 52(4):1495-504. PMC: 4135434. DOI: 10.1016/j.neuroimage.2010.05.011. View

Yairi E, Ambrose N . Epidemiology of stuttering: 21st century advances. J Fluency Disord. 2013; 38(2):66-87. PMC: 3687212. DOI: 10.1016/j.jfludis.2012.11.002. View

Fries P . A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn Sci. 2005; 9(10):474-80. DOI: 10.1016/j.tics.2005.08.011. View

Lu C, Peng D, Chen C, Ning N, Ding G, Li K . Altered effective connectivity and anomalous anatomy in the basal ganglia-thalamocortical circuit of stuttering speakers. Cortex. 2009; 46(1):49-67. DOI: 10.1016/j.cortex.2009.02.017. View

Etchell A, Johnson B, Sowman P . Beta oscillations, timing, and stuttering. Front Hum Neurosci. 2015; 8:1036. PMC: 4283545. DOI: 10.3389/fnhum.2014.01036. View

10.

Chang S, Chow H, Wieland E, McAuley J . Relation between functional connectivity and rhythm discrimination in children who do and do not stutter. Neuroimage Clin. 2016; 12:442-50. PMC: 5008055. DOI: 10.1016/j.nicl.2016.08.021. View

11.

Alm P . Stuttering and the basal ganglia circuits: a critical review of possible relations. J Commun Disord. 2004; 37(4):325-69. DOI: 10.1016/j.jcomdis.2004.03.001. View

12.

Caruso A, Bidinger D, SOMMERS R . Adults who stutter: responses to cognitive stress. J Speech Hear Res. 1994; 37(4):746-54. DOI: 10.1044/jshr.3704.746. View

13.

Wolpert D, Miall R, Kawato M . Internal models in the cerebellum. Trends Cogn Sci. 2011; 2(9):338-47. DOI: 10.1016/s1364-6613(98)01221-2. View

14.

Jancke L, Hanggi J, Steinmetz H . Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004; 4(1):23. PMC: 539354. DOI: 10.1186/1471-2377-4-23. View

15.

Etchell A, Ryan M, Martin E, Johnson B, Sowman P . Abnormal time course of low beta modulation in non-fluent preschool children: A magnetoencephalographic study of rhythm tracking. Neuroimage. 2015; 125:953-963. DOI: 10.1016/j.neuroimage.2015.10.086. View

16.

Friederici A . Language development and the ontogeny of the dorsal pathway. Front Evol Neurosci. 2012; 4:3. PMC: 3272640. DOI: 10.3389/fnevo.2012.00003. View

17.

Mersov A, Jobst C, Cheyne D, De Nil L . Sensorimotor Oscillations Prior to Speech Onset Reflect Altered Motor Networks in Adults Who Stutter. Front Hum Neurosci. 2016; 10:443. PMC: 5009120. DOI: 10.3389/fnhum.2016.00443. View

18.

Walsh B, Tian F, Tourville J, Yucel M, Kuczek T, Bostian A . Hemodynamics of speech production: An fNIRS investigation of children who stutter. Sci Rep. 2017; 7(1):4034. PMC: 5481456. DOI: 10.1038/s41598-017-04357-6. View

19.

Ingham R, Bothe A, Wang Y, Purkhiser K, New A . Phonation interval modification and speech performance quality during fluency-inducing conditions by adults who stutter. J Commun Disord. 2012; 45(3):198-211. PMC: 3334392. DOI: 10.1016/j.jcomdis.2012.01.004. View

20.

Mersov A, Cheyne D, Jobst C, De Nil L . A preliminary study on the neural oscillatory characteristics of motor preparation prior to dysfluent and fluent utterances in adults who stutter. J Fluency Disord. 2017; 55:145-155. DOI: 10.1016/j.jfludis.2017.05.003. View