Chinese Medicines in Diabetic Retinopathy Therapies

Overview

Journal Chin J Integr Med

Date 2018 Sep 29

PMID 30264267

Citations 3

Authors

Wei Song

Yong-Wei Zhu

Affiliations

Soon will be listed here.

Abstract

Diabetic retinopathy (DR), a chronic microvascular retinal disorder leading to retinal nonperfusion and ischemia, is one of the leading causes of blindness among individuals of working age. Inflammation and neovascularization play important roles in the development of DR, especially proliferative DR (PDR). Therapies with Chinese medicines (CMs) that improve microcirculation complementary to conventional treatments increase the chances of delaying PDR development and improving visual acuity in diabetes patients. This review aimed to introduce promising CMs targeting DR patients in clinical practice, together with their underlying molecular mechanisms.

Citing Articles

Exploration of the Potential Mechanisms of Lingqihuangban Granule for Treating Diabetic Retinopathy Based on Network Pharmacology.

He S, Gu C, Su T, Zhou C, Lhamo T, Draga D Comb Chem High Throughput Screen. 2022; 26(1):14-29.

PMID: 35392781 DOI: 10.2174/1386207325666220407112018.

Mechanisms and Active Compounds Polysaccharides and Bibenzyls of Medicinal Dendrobiums for Diabetes Management.

Li M, Trapika I, Tang S, Cho J, Qi Y, Li C Front Nutr. 2022; 8:811870.

PMID: 35155528 PMC: 8832146. DOI: 10.3389/fnut.2021.811870.

Saikosaponin D inhibits proliferation of human osteosarcoma cells via the p53 signaling pathway.

Zhao L, Li J, Sun Z, Sun C, Yu Z, Guo X Exp Ther Med. 2019; 17(1):488-494.

PMID: 30651826 PMC: 6307437. DOI: 10.3892/etm.2018.6969.

References

Kobayashi S, Kimura I, Fukuta M, Kontani H, Inaba K, Niwa M . Inhibitory effects of tetrandrine and related synthetic compounds on angiogenesis in streptozotocin-diabetic rodents. Biol Pharm Bull. 1999; 22(4):360-5. DOI: 10.1248/bpb.22.360. View

Liang X, Hagino N, Guo S, Tsutsumi T, Kobayashi S . Therapeutic efficacy of Stephania tetrandra S. Moore for treatment of neovascularization of retinal capillary (retinopathy) in diabetes--in vitro study. Phytomedicine. 2002; 9(5):377-84. DOI: 10.1078/09447110260571599. View

Joussen A, Poulaki V, Le M, Koizumi K, Esser C, Janicki H . A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004; 18(12):1450-2. DOI: 10.1096/fj.03-1476fje. View

Kogure T, Hoshino A, Ito K, Sato H, Tatsumi T, Ohyama Y . Beneficial effect of complementary alternative medicine on lymphedema with rheumatoid arthritis. Mod Rheumatol. 2006; 15(6):445-9. DOI: 10.1007/s10165-005-0438-2. View

Zhao Y, Son Y, Kim S, Jang Y, Lee J . Antioxidant and anti-hyperglycemic activity of polysaccharide isolated from Dendrobium chrysotoxum Lindl. J Biochem Mol Biol. 2007; 40(5):670-7. DOI: 10.5483/bmbrep.2007.40.5.670. View

Zhang X, Bao S, Lai D, Rapkins R, Gillies M . Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes. 2008; 57(4):1026-33. PMC: 2836241. DOI: 10.2337/db07-0982. View

Teng Y, Cui H, Yang M, Song H, Zhang Q, Su Y . Protective effect of puerarin on diabetic retinopathy in rats. Mol Biol Rep. 2008; 36(5):1129-33. DOI: 10.1007/s11033-008-9288-2. View

Kim J, Kim J, Lee Y, Ahn E, Kim K, Yu Y . Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation. Mol Vis. 2009; 15:1868-75. PMC: 2743803. View

Luo X, Duan J, Liao P, Wu L, Yu Y, Qiu B . Effect of qiming granule on retinal blood circulation of diabetic retinopathy: a multicenter clinical trial. Chin J Integr Med. 2009; 15(5):384-8. DOI: 10.1007/s11655-009-0384-5. View

10.

Liou G . Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation. World J Diabetes. 2011; 1(1):12-8. PMC: 3083879. DOI: 10.4239/wjd.v1.i1.12. View

11.

Tang J, Kern T . Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011; 30(5):343-58. PMC: 3433044. DOI: 10.1016/j.preteyeres.2011.05.002. View

12.

Shang X, Pan H, Li M, Miao X, Ding H . Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol. 2011; 138(1):1-21. PMC: 7127058. DOI: 10.1016/j.jep.2011.08.016. View

13.

Lim J, Chan T, Ng D, Sagineedu S, Stanslas J, Wong W . Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clin Exp Pharmacol Physiol. 2011; 39(3):300-10. DOI: 10.1111/j.1440-1681.2011.05633.x. View

14.

Yau J, Rogers S, Kawasaki R, Lamoureux E, Kowalski J, Bek T . Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012; 35(3):556-64. PMC: 3322721. DOI: 10.2337/dc11-1909. View

15.

Gao D, Guo Y, Li X, Li X, Li Z, Xue M . An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy. Evid Based Complement Alternat Med. 2013; 2013:578165. PMC: 3638602. DOI: 10.1155/2013/578165. View

16.

Jiang M, Han Y, Zhou M, Zhao H, Xiao X, Hou Y . The screening research of anti-inflammatory bioactive markers from different flowering phases of Flos Lonicerae Japonicae. PLoS One. 2014; 9(5):e96214. PMC: 4014484. DOI: 10.1371/journal.pone.0096214. View

17.

Gong C, Yu Z, Lu B, Yang L, Sheng Y, Fan Y . Ethanol extract of Dendrobium chrysotoxum Lindl ameliorates diabetic retinopathy and its mechanism. Vascul Pharmacol. 2014; 62(3):134-42. DOI: 10.1016/j.vph.2014.04.007. View

18.

Lee Y, Kim C, Sohn E, Jo K, Lim H, Kim S . Sipjeondaebo-tang, a traditional herbal formula, inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy. Tohoku J Exp Med. 2014; 234(3):229-36. DOI: 10.1620/tjem.234.229. View

19.

Zhu X, Xie M, Wang K, Zhang K, Gao Y, Zhu L . The effect of puerarin against IL-1β-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). Mol Vis. 2015; 20:1815-23. PMC: 4287719. View

20.

Yu Z, Lu B, Sheng Y, Zhou L, Ji L, Wang Z . Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation. Biochim Biophys Acta. 2015; 1850(4):824-31. DOI: 10.1016/j.bbagen.2015.01.014. View