Dietary Hydroxycinnamates Prevent Oxidative Damages to Liver, Spleen, and Bone Marrow Cells in Irradiation-exposed Mice

Overview

Journal Food Sci Biotechnol

Specialty Biotechnology

Date 2018 Sep 29

PMID 30263539

Citations 3

Authors

Sung-Ho Kook

Sa-Ra Cheon

Jae-Hwan Kim

Ki-Choon Choi

Min-Kook Kim

Jeong-Chae Lee

Affiliations

Soon will be listed here.

Abstract

Dietary hydroxycinnamates are considered as attractive materials for radioprotection. This study explores whether hydroxycinnamates protect against γ-radiation-induced cellular damages and hematopoietic stem cell senescence. C57BL/6 mice were orally administered with each of caffeic acid, p-coumaric acid, and ferulic acid (20mg/kg body weight) once per three days for five times before exposure to total body radiation (5 Gy). Irradiation increased the activities of alanine amino transaminase and aspartate aminotransferase in blood serum but decreased the anti-oxidant defense enzyme activities in the liver and spleen tissues. Oral administration of the compounds almost completely prevented irradiation-mediated changes in these enzyme activities. The hydroxycinnamates also inhibited the irradiation-mediated increases in the mitochondrial superoxide anions of LinSca-1c-Kit (LSK) cells and CD150CD48 LSK cells in the bone marrow. These results suggest that dietary hydroxycinnamates protect against irradiation-mediated oxidative damages of tissues and bone marrow progenitor cells.

Citing Articles

Amelioration of radiation-induced liver damage by -coumaric acid in mice.

Li Y, Wu J, He Q, Gu J, Zhang L, Niu H Food Sci Biotechnol. 2022; 31(10):1315-1323.

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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence.

Varesi A, Chirumbolo S, Campagnoli L, Pierella E, Piccini G, Carrara A Antioxidants (Basel). 2022; 11(7).

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Supplemental Ferulic Acid Inhibits Total Body Irradiation-Mediated Bone Marrow Damage, Bone Mass Loss, Stem Cell Senescence, and Hematopoietic Defect in Mice by Enhancing Antioxidant Defense Systems.

Wagle S, Sim H, Bhattarai G, Choi K, Kook S, Lee J Antioxidants (Basel). 2021; 10(8).

PMID: 34439457 PMC: 8388974. DOI: 10.3390/antiox10081209.

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