Adipogenesis Inhibitory Effects of in Mouse Bone Marrow Stromal D1 Cells

Overview

Journal Food Sci Biotechnol

Specialty Biotechnology

Date 2018 Sep 29

PMID 30263497

Citations 3

Authors

Myeong Sook Kwon

Fatih Karadeniz

Jung-Ae Kim

Youngwan Seo

Chang-Suk Kong

Affiliations

Soon will be listed here.

Abstract

Unbalanced differentiation of bone marrow cells into adipocytes rather than osteoblasts causes severe bone-related disorders, such as osteoporosis. Natural products that can act against unbalanced differentiation are targeted for development of functional dietary supplements. , a halophyte known for anti-oxidant constituents, was studied for beneficial effects in prevention of adipogenesis of bone marrow stromal D1 cells . Solvent-partitioned extract fractions of prevented differentiating D1 cells from accumulating lipids. Expression of the key adipogenic markers PPARγ, SREBP1c, and C/EBPα were inhibited at mRNA and protein levels. Suppressed protein levels of the phosphorylated MAPK-related factors ERK, JNK, and p-38 indicated inhibition of PPARγ pathway-linked adipogenesis in D1 cells. The n-BuOH fraction was the most effective fraction for bioactive substances. inhibited adipogenesis in D1 bone marrow stromal cells due to the presence of bioactive flavonoids.

Citing Articles

Positive Regulation of Acetate in Adipocyte Differentiation and Lipid Deposition in Obese Mice.

Sun C, Li A, Wang H, Ma J, Hou J Nutrients. 2023; 15(17).

PMID: 37686768 PMC: 10489952. DOI: 10.3390/nu15173736.

Anticatabolic and Anti-Inflammatory Effects of Myricetin 3-O-β-d-Galactopyranoside in UVA-Irradiated Dermal Cells via Repression of MAPK/AP-1 and Activation of TGFβ/Smad.

Oh J, Karadeniz F, Lee J, Park S, Seo Y, Kong C Molecules. 2020; 25(6).

PMID: 32183404 PMC: 7144112. DOI: 10.3390/molecules25061331.

MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte .

Bae M, Karadeniz F, Oh J, Yu G, Jang M, Nam K Evid Based Complement Alternat Med. 2017; 2017:6750274.

PMID: 29234420 PMC: 5632445. DOI: 10.1155/2017/6750274.

References

Clarke B . Corticosteroid-induced osteoporosis: an update for dermatologists. Am J Clin Dermatol. 2012; 13(3):167-90. DOI: 10.2165/11594250-000000000-00000. View

Yao W, Cheng Z, Busse C, Pham A, Nakamura M, Lane N . Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: a longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice. Arthritis Rheum. 2008; 58(6):1674-86. PMC: 3892702. DOI: 10.1002/art.23454. View

Cao J . Effects of obesity on bone metabolism. J Orthop Surg Res. 2011; 6:30. PMC: 3141563. DOI: 10.1186/1749-799X-6-30. View

Xiao J, Ni X, Kai G, Chen X . Advance in dietary polyphenols as aldose reductases inhibitors: structure-activity relationship aspect. Crit Rev Food Sci Nutr. 2014; 55(1):16-31. DOI: 10.1080/10408398.2011.584252. View

Meot-Duros L, Le Floch G, Magne C . Radical scavenging, antioxidant and antimicrobial activities of halophytic species. J Ethnopharmacol. 2008; 116(2):258-62. DOI: 10.1016/j.jep.2007.11.024. View

Krey G, Braissant O, LHorset F, Kalkhoven E, Perroud M, Parker M . Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol. 1997; 11(6):779-91. DOI: 10.1210/mend.11.6.0007. View

Manolagas S, Jilka R . Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 1995; 332(5):305-11. DOI: 10.1056/NEJM199502023320506. View

Kim Y, Kong C, Lee J, Kim H, Park H, Lee H . Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea. Bioorg Med Chem Lett. 2012; 22(13):4318-22. DOI: 10.1016/j.bmcl.2012.05.017. View

Rosen E, MacDougald O . Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol. 2006; 7(12):885-96. DOI: 10.1038/nrm2066. View

10.

Rodriguez-Mateos A, Vauzour D, Krueger C, Shanmuganayagam D, Reed J, Calani L . Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol. 2014; 88(10):1803-53. DOI: 10.1007/s00204-014-1330-7. View

11.

Sohretoglu D, Sabuncuoglu S . Secondary metabolites, cytotoxic response by neutral red retention and protective effect against H2O2 induced cytotoxicity of Sedum caespitosum. Nat Prod Commun. 2012; 7(1):39-40. View

12.

Gimble J, ROBINSON C, Wu X, Kelly K, Rodriguez B, Kliewer S . Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol. 1996; 50(5):1087-94. View

13.

Bost F, Aouadi M, Caron L, Binetruy B . The role of MAPKs in adipocyte differentiation and obesity. Biochimie. 2005; 87(1):51-6. DOI: 10.1016/j.biochi.2004.10.018. View

14.

Berger J, Moller D . The mechanisms of action of PPARs. Annu Rev Med. 2002; 53:409-35. DOI: 10.1146/annurev.med.53.082901.104018. View