Exploring Photosensitization As an Efficient Antifungal Method

Overview

Journal Sci Rep

Specialty Science

Date 2018 Sep 29

PMID 30262914

Citations 2

Authors

Cesar Espinoza

Miriam C Rodriguez Gonzalez

Guillermo Mendoza

Alberto Hernandez Creus

Angel Trigos

Jose J Fernandez

Affiliations

Soon will be listed here.

Abstract

Lipid bilayers containing ergosterol show signs of destruction when they are treated with singlet oxygen, due to the conversion of ergosterol into its peroxy derivative. Applying this previous knowledge, an antifungal method was explored using Candida tropicalis as model, and membrane permeation under photosensitization conditions became evident. These data were complemented through AFM images of artificial lipid bilayers, using cholesterol or ergosterol as structural sterols, showing their corresponding morphologies at the nanoscale. Based on these results, an antifungal method was developed, which shows evidence of the extent of membrane permeation during photosensitization. Such photosensitization offers an effective alternative treatment, especially in membranes with a high ergosterol content, suggesting that this procedure constitutes an easy and efficient antifungal method.

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