Updates on T Helper Type 17 Immunity in Respiratory Disease

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2018 Sep 28

PMID 30260473

Citations 40

Authors

Naoki Iwanaga

Jay K Kolls

Affiliations

Soon will be listed here.

Abstract

Interleukin-17 (IL-17)-producing cells play a critical role in mucosal immunity including the respiratory tract. This review will highlight recent advances in our understanding of these cells in mucosal immunity in the lung as well as their potential pathogenic roles in respiratory diseases. The IL-17-producing cells include γδ T cells, natural killer cells, group 3 innate lymphoid cells, and T helper type 17 (Th17) cells. There have been recent advances in our understanding of these cell populations in the lung as well as emerging data on how these cells are regulated in the lung. Moreover, Th17 cells may be a key component of tissue-resident memory cells that may be acquired over time or elicited by mucosal immunization that provides the host with enhanced immunity against certain pathogens.

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References

Woodruff P, Modrek B, Choy D, Jia G, Abbas A, Ellwanger A . T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009; 180(5):388-95. PMC: 2742757. DOI: 10.1164/rccm.200903-0392OC. View

Faner R, Cruz T, Casserras T, Lopez-Giraldo A, Noell G, Coca I . Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema. Am J Respir Crit Care Med. 2016; 193(11):1242-53. DOI: 10.1164/rccm.201507-1311OC. View

Corvol H, Blackman S, Boelle P, Gallins P, Pace R, Stonebraker J . Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis. Nat Commun. 2015; 6:8382. PMC: 4589222. DOI: 10.1038/ncomms9382. View

Chan Y, Chen K, Duncan S, Lathrop K, Latoche J, Logar A . Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes. J Allergy Clin Immunol. 2012; 131(4):1117-29, 1129.e1-5. PMC: 3488163. DOI: 10.1016/j.jaci.2012.05.036. View

Happel K, Zheng M, Young E, Quinton L, Lockhart E, Ramsay A . Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol. 2003; 170(9):4432-6. PMC: 2841978. DOI: 10.4049/jimmunol.170.9.4432. View

Minegishi Y, Karasuyama H . Genetic origins of hyper-IgE syndrome. Curr Allergy Asthma Rep. 2008; 8(5):386-91. DOI: 10.1007/s11882-008-0075-x. View

Kumar B, Ma W, Miron M, Granot T, Guyer R, Carpenter D . Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites. Cell Rep. 2017; 20(12):2921-2934. PMC: 5646692. DOI: 10.1016/j.celrep.2017.08.078. View

Malley R, Anderson P . Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity. Proc Natl Acad Sci U S A. 2012; 109(10):3623-7. PMC: 3309758. DOI: 10.1073/pnas.1121383109. View

Tan H, Regamey N, Brown S, Bush A, Lloyd C, Davies J . The Th17 pathway in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2011; 184(2):252-8. PMC: 3381840. DOI: 10.1164/rccm.201102-0236OC. View

10.

Li J, Casanova J, Puel A . Mucocutaneous IL-17 immunity in mice and humans: host defense vs. excessive inflammation. Mucosal Immunol. 2017; 11(3):581-589. PMC: 5975098. DOI: 10.1038/mi.2017.97. View

11.

Pezzulo A, Tang X, Hoegger M, Abou Alaiwa M, Ramachandran S, Moninger T . Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature. 2012; 487(7405):109-13. PMC: 3390761. DOI: 10.1038/nature11130. View

12.

Wuthrich M, Gern B, Hung C, Ersland K, Rocco N, Pick-Jacobs J . Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest. 2011; 121(2):554-68. PMC: 3026727. DOI: 10.1172/JCI43984. View

13.

Raundhal M, Morse C, Khare A, Oriss T, Milosevic J, Trudeau J . High IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015; 125(8):3037-50. PMC: 4563754. DOI: 10.1172/JCI80911. View

14.

Eddens T, Elsegeiny W, Garcia-Hernadez M, Castillo P, Trevejo-Nunez G, Serody K . Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity. Cell Rep. 2017; 18(13):3078-3090. PMC: 5411079. DOI: 10.1016/j.celrep.2017.03.016. View

15.

Forbes L, Milner J, Haddad E . Signal transducer and activator of transcription 3: a year in review. Curr Opin Hematol. 2015; 23(1):23-7. PMC: 4790836. DOI: 10.1097/MOH.0000000000000206. View

16.

Okada S, Markle J, Deenick E, Mele F, Averbuch D, Lagos M . IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science. 2015; 349(6248):606-613. PMC: 4668938. DOI: 10.1126/science.aaa4282. View

17.

Stoltz D, Meyerholz D, Pezzulo A, Ramachandran S, Rogan M, Davis G . Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med. 2010; 2(29):29ra31. PMC: 2889616. DOI: 10.1126/scitranslmed.3000928. View

18.

Shah V, Meyerholz D, Tang X, Reznikov L, Abou Alaiwa M, Ernst S . Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science. 2016; 351(6272):503-7. PMC: 4852973. DOI: 10.1126/science.aad5589. View

19.

Chien Y, Zeng X, Prinz I . The natural and the inducible: interleukin (IL)-17-producing γδ T cells. Trends Immunol. 2012; 34(4):151-4. PMC: 3622789. DOI: 10.1016/j.it.2012.11.004. View

20.

Yang X, Panopoulos A, Nurieva R, Chang S, Wang D, Watowich S . STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007; 282(13):9358-9363. DOI: 10.1074/jbc.C600321200. View