A Novel Guanine N3 Alkylation by Antitumor Antibiotic Duocarmycin A

Overview

Journal Tetrahedron Lett

Publisher Elsevier

Specialty Chemistry

Date 2018 Sep 28

PMID 30260344

Citations 4

Authors

H Sugiyama

K Ohmori

K L Chan

M Hosoda

A Asai

H Saito

I Saito

Affiliations

Soon will be listed here.

Abstract

Antitumor antibiotic duocarmycin A was found to undergo a novel N3 alkylation of the guanine residue (G7) of d(GCAATTGC)2. Guanine base was shown to be a second major target of duocarmycin A in DNA.

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