HBV Vaccine and Risk of Developing Multiple Sclerosis: a Systematic Review and Meta-analysis

Overview

Journal Hum Vaccin Immunother

Specialty Allergy & Immunology

Date 2018 Sep 28

PMID 30260264

Citations 7

Authors

Cristina Sestili

Ines Grazina

Giuseppe La Torre

Affiliations

Soon will be listed here.

Abstract

Hepatitis B virus (HBV) infection is one the most common in the world. Aim of this study is to perform a systematic review on the relationship between HBV vaccination and multiple sclerosis. Research was conducted on Pubmed, ISI Web of Science, and Scopus. Terms " and "" were used. Meta-analysis and metaregression were performed. 414 papers were found. Seven articles were selected. For the reported crude risk estimates for MS no statistically significant association was observed with pooled OR 1,19 (95%CI: 0,96-1,49). For the adjusted ORs, the pooled odds ratio (OR) was 0, 965 (95%CI: 0,886- 1,051). Meta regression show that year of publication is negatively (β: -0,019; P < 0.001) and NOS score and publishing in Europe are positively associated with O.R. value. Funnel plot showed the presence of publication bias. Results showed that Hepatitis B vaccination is not associated with an increased risk of developing MS.

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References

Martinez-Sernandez V, Figueiras A . Central nervous system demyelinating diseases and recombinant hepatitis B vaccination: a critical systematic review of scientific production. J Neurol. 2012; 260(8):1951-9. DOI: 10.1007/s00415-012-6716-y. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

Belbasis L, Bellou V, Evangelou E, Ioannidis J, Tzoulaki I . Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. Lancet Neurol. 2015; 14(3):263-73. DOI: 10.1016/S1474-4422(14)70267-4. View

Hernan M, Jick S, Olek M, Jick H . Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study. Neurology. 2004; 63(5):838-42. DOI: 10.1212/01.wnl.0000138433.61870.82. View

Touze E, Gout O, Lyon-Caen O, Alperovitch A . [The first episode of central nervous system demyelinization and hepatitis B virus vaccination]. Rev Neurol (Paris). 2000; 156(3):242-6. View

Gout O, Lyon-Caen O . [Sclerotic plaques and vaccination against hepatitis B]. Rev Neurol (Paris). 1998; 154(3):205-7. View

Lok A, McMahon B . Chronic hepatitis B. Hepatology. 2007; 45(2):507-39. DOI: 10.1002/hep.21513. View

Touze E, Fourrier A, Jeantaud I, Begaud B, Alperovitch A . Hepatitis B vaccination and first central nervous system demyelinating event: a case-control study. Neuroepidemiology. 2002; 21(4):180-6. DOI: 10.1159/000059520. View

Mikaeloff Y, Caridade G, Rossier M, Suissa S, Tardieu M . Hepatitis B vaccination and the risk of childhood-onset multiple sclerosis. Arch Pediatr Adolesc Med. 2007; 161(12):1176-82. DOI: 10.1001/archpedi.161.12.1176. View

10.

Mikaeloff Y, Caridade G, Suissa S, Tardieu M . Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood. Neurology. 2008; 72(10):873-80. DOI: 10.1212/01.wnl.0000335762.42177.07. View

11.

Hocine M, Farrington C, Touze E, Whitaker H, Fourrier A, Moreau T . Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series method. Vaccine. 2007; 25(31):5938-43. DOI: 10.1016/j.vaccine.2007.05.032. View

12.

Ramagopalan S, Valdar W, Dyment D, DeLuca G, Yee I, Giovannoni G . Association of infectious mononucleosis with multiple sclerosis. A population-based study. Neuroepidemiology. 2009; 32(4):257-62. DOI: 10.1159/000201564. View

13.

Ascherio A, Zhang S, Hernan M, Olek M, Coplan P, Brodovicz K . Hepatitis B vaccination and the risk of multiple sclerosis. N Engl J Med. 2001; 344(5):327-32. DOI: 10.1056/NEJM200102013440502. View

14.

Eftekharian M, Mousavi M, Hormoz M, Roshanaei G, Mazdeh M . Multiple sclerosis and immunological-related risk factors: results from a case-control study. Hum Antibodies. 2015; 23(1-2):31-6. DOI: 10.3233/HAB-150281. View

15.

Rutschmann O, McCrory D, Matchar D . Immunization and MS: a summary of published evidence and recommendations. Neurology. 2002; 59(12):1837-43. DOI: 10.1212/wnl.59.12.1837. View

16.

Marrie R, Wolfson C, Sturkenboom M, Gout O, Heinzlef O, Roullet E . Multiple sclerosis and antecedent infections: a case-control study. Neurology. 2000; 54(12):2307-10. DOI: 10.1212/wnl.54.12.2307. View

17.

Langer-Gould A, Qian L, Tartof S, Brara S, Jacobsen S, Beaber B . Vaccines and the risk of multiple sclerosis and other central nervous system demyelinating diseases. JAMA Neurol. 2014; 71(12):1506-13. DOI: 10.1001/jamaneurol.2014.2633. View

18.

Mouchet J, Salvo F, Raschi E, Poluzzi E, Antonazzo I, De Ponti F . Hepatitis B vaccination and the putative risk of central demyelinating diseases - A systematic review and meta-analysis. Vaccine. 2018; 36(12):1548-1555. DOI: 10.1016/j.vaccine.2018.02.036. View

19.

Ott J, Stevens G, Groeger J, Wiersma S . Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012; 30(12):2212-9. DOI: 10.1016/j.vaccine.2011.12.116. View

20.

Farez M, Correale J . Immunizations and risk of multiple sclerosis: systematic review and meta-analysis. J Neurol. 2011; 258(7):1197-206. DOI: 10.1007/s00415-011-5984-2. View