PACAP/PAC1 Expression and Function in Micturition Pathways

Overview

Journal J Mol Neurosci

Specialties Molecular Biology
Neurology

Date 2018 Sep 28

PMID 30259317

Citations 13

Authors

Jacqueline Ojala

Katharine Tooke

Harrison Hsiang

Beatrice M Girard

Victor May

Margaret A Vizzard

Affiliations

Soon will be listed here.

Abstract

Neural injury, inflammation, or diseases commonly and adversely affect micturition reflex function that is organized by neural circuits in the CNS and PNS. One neuropeptide receptor system, pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1), and its cognate receptor, PAC1 (Adcyap1r1), have tissue-specific distributions in the lower urinary tract. PACAP and associated receptors are expressed in the LUT and exhibit changes in expression, distribution, and function in preclinical animal models of bladder pain syndrome (BPS)/interstitial cystitis (IC), a chronic, visceral pain syndrome characterized by pain, and LUT dysfunction. Blockade of the PACAP/PAC1 receptor system reduces voiding frequency and somatic (e.g., hindpaw, pelvic) sensitivity in preclinical animal models and a transgenic mouse model that mirrors some clinical symptoms of BPS/IC. The PACAP/receptor system in micturition pathways may represent a potential target for therapeutic intervention to reduce LUT dysfunction following urinary bladder inflammation.

Citing Articles

PACAP/PAC1 regulation in cystitis rats: induction of bladder inflammation cascade leading to bladder dysfunction.

Ke H, Zhu L, Zhang W, Wang H, Ding Z, Su D Front Immunol. 2024; 15:1413078.

PMID: 39669574 PMC: 11634801. DOI: 10.3389/fimmu.2024.1413078.

Exploring the Role of Neuropeptide PACAP in Cytoskeletal Function Using Spectroscopic Methods.

Vekony R, Tamas A, Lukacs A, Ujfalusi Z, Lorinczy D, Takacs-Kollar V Int J Mol Sci. 2024; 25(15).

PMID: 39125632 PMC: 11311697. DOI: 10.3390/ijms25158063.

From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment.

Tanaka M, Szabo A, Kortesi T, Szok D, Tajti J, Vecsei L Cells. 2023; 12(22).

PMID: 37998384 PMC: 10670698. DOI: 10.3390/cells12222649.

Differential Influences of Endogenous and Exogenous Sensory Neuropeptides on the ATP Metabolism by Soluble Ectonucleotidases in the Murine Bladder Lamina Propria.

Gutierrez Cruz A, Aresta Branco M, Borhani Peikani M, Mutafova-Yambolieva V Int J Mol Sci. 2023; 24(21).

PMID: 37958631 PMC: 10647406. DOI: 10.3390/ijms242115650.

Changes in nerve growth factor signaling in female mice with cyclophosphamide-induced cystitis.

Hsiang H, Girard B, Vizzard M Front Urol. 2023; 2.

PMID: 37701183 PMC: 10493645. DOI: 10.3389/fruro.2022.1089220.

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