Age-related Changes in Skeletal Muscle: Changes to Life-style As a Therapy

Overview

Journal Biogerontology

Specialty Geriatrics

Date 2018 Sep 28

PMID 30259289

Citations 81

Authors

Rachel McCormick

Aphrodite Vasilaki

Affiliations

Soon will be listed here.

Abstract

As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with changes in numerous important mechanisms all contributing to the structural and functional deterioration. Here, we review the major proposed changes which occur in skeletal muscle during ageing and highlight evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting.

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