Analysis of Risk Factors for New Vertebral Fracture After Percutaneous Vertebroplasty

Overview

Journal Global Spine J

Publisher Sage Publications

Date 2018 Sep 28

PMID 30258749

Citations 12

Authors

Matias Borensztein

Gaston O Camino Willhuber

Maria Lourdes Posadas Martinez

Marcelo Gruenberg

Carlos A Sola

Osvaldo Velan

Affiliations

Soon will be listed here.

Abstract

Study Design: Retrospective analysis. Level of evidence III.

Objectives: Low-energy vertebral compression fractures are an increasing socioeconomic problem among elderly patients. Percutaneous vertebroplasty has been extensively used for the treatment of painful fractures because of its effectiveness. However, some complications have been described; among them, new vertebral compression fractures, whether adjacent or not to the treated vertebra, are commonly reported complications (8% to 52%).

Methods: We retrospectively analyzed epidemiological and technical variables presumably associated with new vertebral compression fractures. To determine the relationship between new vertebral compression fracture and percutaneous vertebroplasty, 30 patients (study group) with this complication were compared with 60 patients treated with percutaneous vertebroplasty without this condition (control group).

Results: A higher cement percentage was found in the study group (40.3%) compared with the control group (30.5%). Initial vertebral kyphosis was significantly higher in the first group (15°) compared with the control group (9°). Epidemiological factors were similar in both groups.

Conclusions: In our study, increased cement percentage injected and a higher kyphosis were associated with new vertebral compression fractures.

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References

Jensen M, Evans A, Mathis J, Kallmes D, Cloft H, Dion J . Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects. AJNR Am J Neuroradiol. 1997; 18(10):1897-904. PMC: 8337380. View

Lin W, Cheng T, Lee Y, Wang T, Cheng Y, Lui C . New vertebral osteoporotic compression fractures after percutaneous vertebroplasty: retrospective analysis of risk factors. J Vasc Interv Radiol. 2008; 19(2 Pt 1):225-31. DOI: 10.1016/j.jvir.2007.09.008. View

Baroud G, Heini P, Nemes J, Bohner M, Ferguson S, Steffen T . Biomechanical explanation of adjacent fractures following vertebroplasty. Radiology. 2003; 229(2):606-7. DOI: 10.1148/radiol.2292030378. View

Voormolen M, Lohle P, Juttmann J, van der Graaf Y, Fransen H, Lampmann L . The risk of new osteoporotic vertebral compression fractures in the year after percutaneous vertebroplasty. J Vasc Interv Radiol. 2006; 17(1):71-6. DOI: 10.1097/01.RVI.0000190910.43602.3C. View

Uppin A, Hirsch J, Centenera L, Pfiefer B, Pazianos A, Choi I . Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis. Radiology. 2003; 226(1):119-24. DOI: 10.1148/radiol.2261011911. View

Takahara K, Kamimura M, Moriya H, Ashizawa R, Koike T, Hidai Y . Risk factors of adjacent vertebral collapse after percutaneous vertebroplasty for osteoporotic vertebral fracture in postmenopausal women. BMC Musculoskelet Disord. 2016; 17:12. PMC: 4711009. DOI: 10.1186/s12891-016-0887-0. View

Lin E, Ekholm S, Hiwatashi A, Westesson P . Vertebroplasty: cement leakage into the disc increases the risk of new fracture of adjacent vertebral body. AJNR Am J Neuroradiol. 2004; 25(2):175-80. PMC: 7974625. View

Trout A, Kallmes D, Kaufmann T . New fractures after vertebroplasty: adjacent fractures occur significantly sooner. AJNR Am J Neuroradiol. 2006; 27(1):217-23. PMC: 7976057. View

Nieuwenhuijse M, Bollen L, van Erkel A, Dijkstra P . Optimal intravertebral cement volume in percutaneous vertebroplasty for painful osteoporotic vertebral compression fractures. Spine (Phila Pa 1976). 2012; 37(20):1747-55. DOI: 10.1097/BRS.0b013e318254871c. View

10.

Anselmetti G, Marcia S, Saba L, Muto M, Bonaldi G, Carpeggiani P . Percutaneous vertebroplasty: multi-centric results from EVEREST experience in large cohort of patients. Eur J Radiol. 2012; 81(12):4083-6. DOI: 10.1016/j.ejrad.2012.07.005. View

11.

Liebschner M, Rosenberg W, Keaveny T . Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty. Spine (Phila Pa 1976). 2001; 26(14):1547-54. DOI: 10.1097/00007632-200107150-00009. View

12.

Tseng Y, Yang S, Tu P, Yang T, Lo Y . Minimally invasive vertebroplasty in the treatment of pain induced by spinal metastatic tumor. Minim Invasive Neurosurg. 2008; 51(5):280-4. DOI: 10.1055/s-0028-1082328. View

13.

Lee D, Park C, Park C, Lee D, Hwang J . Analysis of Risk Factors Causing New Symptomatic Vertebral Compression Fractures After Percutaneous Vertebroplasty for Painful Osteoporotic Vertebral Compression Fractures: A 4-year Follow-up. J Spinal Disord Tech. 2013; 28(10):E578-83. DOI: 10.1097/BSD.0000000000000043. View

14.

Ma X, Xing D, Ma J, Wang J, Chen Y, Xu W . Risk factors for new vertebral compression fractures after percutaneous vertebroplasty: qualitative evidence synthesized from a systematic review. Spine (Phila Pa 1976). 2013; 38(12):E713-22. DOI: 10.1097/BRS.0b013e31828cf15b. View

15.

Komemushi A, Tanigawa N, Kariya S, Kojima H, Shomura Y, Komemushi S . Percutaneous vertebroplasty for osteoporotic compression fracture: multivariate study of predictors of new vertebral body fracture. Cardiovasc Intervent Radiol. 2006; 29(4):580-5. DOI: 10.1007/s00270-005-0138-5. View

16.

Aquarius R, van der Zijden A, Homminga J, Verdonschot N, Tanck E . Does bone cement in percutaneous vertebroplasty act as a stress riser?. Spine (Phila Pa 1976). 2013; 38(24):2092-7. DOI: 10.1097/01.brs.0000435029.88434.97. View

17.

Yeom J, Kim W, Choy W, Lee C, Chang B, Kang J . Leakage of cement in percutaneous transpedicular vertebroplasty for painful osteoporotic compression fractures. J Bone Joint Surg Br. 2003; 85(1):83-9. DOI: 10.1302/0301-620x.85b1.13026. View

18.

Zhang Z, Fan J, Ding Q, Wu M, Yin G . Risk factors for new osteoporotic vertebral compression fractures after vertebroplasty: a systematic review and meta-analysis. J Spinal Disord Tech. 2012; 26(4):E150-7. DOI: 10.1097/BSD.0b013e31827412a5. View

19.

Laredo J, Hamze B . Complications of percutaneous vertebroplasty and their prevention. Skeletal Radiol. 2004; 33(9):493-505. DOI: 10.1007/s00256-004-0776-8. View

20.

Baroud G, Nemes J, Heini P, Steffen T . Load shift of the intervertebral disc after a vertebroplasty: a finite-element study. Eur Spine J. 2003; 12(4):421-6. PMC: 3467784. DOI: 10.1007/s00586-002-0512-9. View