Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Sep 28

PMID 30258450

Citations 13

Authors

Shengxia Yin

Jingjing Yu

Bian Hu

Chenyu Lu

Xia Liu

Xianzhi Gao

Wei Li

Lina Zhou

Jianli Wang

Di Wang

Linrong Lu

Lie Wang

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs) are the most recently identified family of the innate immune system and are hypothesized to modulate immune functions prior to the generation of adaptive immune responses. Subsets of ILCs reside in the mucosa and regulate immune responses to external pathogens; however, their role and the mechanism by which they protect against intracellular bacterial infection is not completely understood. In this report, using and , we found that the levels of group 1 ILCs and NCR ILC3s were increased upon infection and that these increases were associated with Runt-related transcription factor 3 (Runx3) expression. Runx3 PLZF-cre mice were much more sensitive to infection with the intracellular bacterial pathogens and partially due to abnormal Group 1 ILC and NCRILC3 function. We also found that Runx3 directly binds to the β promoter and intron 8 to accelerate the expression of Il12Rβ2 and modulates IFNγ secretion triggered by the IL12/ STAT4 axis. Therefore, we demonstrate that Runx3 influences group 1 ILC- and NCR+ILC3-mediated immune protection against intracellular bacterial infections of both the gut and liver.

Citing Articles

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