Investigation of Post-translational Modifications in Type 2 Diabetes

Overview

Journal Clin Proteomics

Publisher Biomed Central

Date 2018 Sep 28

PMID 30258344

Citations 16

Authors

Bhaswati Chatterjee

Suman S Thakur

Affiliations

Soon will be listed here.

Abstract

The investigation of post-translational modifications (PTMs) plays an important role for the study of type 2 diabetes. The importance of PTMs has been realized with the advancement of analytical techniques. The challenging detection and analysis of post-translational modifications is eased by different enrichment methods and by high throughput mass spectrometry based proteomics studies. This technology along with different quantitation methods provide accurate knowledge about the changes happening in disease conditions as well as in normal conditions. In this review, we have discussed PTMs such as phosphorylation, N-glycosylation, O-GlcNAcylation, acetylation and advanced glycation end products in type 2 diabetes which have been characterized by high throughput mass spectrometry based proteomics analysis.

Citing Articles

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Optimized protocol for shotgun label-free proteomic analysis of pancreatic islets.

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References

Boersema P, Foong L, Ding V, Lemeer S, van Breukelen B, Philp R . In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labeling. Mol Cell Proteomics. 2009; 9(1):84-99. PMC: 2808269. DOI: 10.1074/mcp.M900291-MCP200. View

Vosseller K, Wells L, Lane M, Hart G . Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2002; 99(8):5313-8. PMC: 122766. DOI: 10.1073/pnas.072072399. View

Rush J, Moritz A, Lee K, Guo A, Goss V, Spek E . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2004; 23(1):94-101. DOI: 10.1038/nbt1046. View

Wang Z, Udeshi N, OMalley M, Shabanowitz J, Hunt D, Hart G . Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry. Mol Cell Proteomics. 2009; 9(1):153-60. PMC: 2808261. DOI: 10.1074/mcp.M900268-MCP200. View

Vosseller K, Trinidad J, Chalkley R, Specht C, Thalhammer A, Lynn A . O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2006; 5(5):923-34. DOI: 10.1074/mcp.T500040-MCP200. View

Li J, Li Q, Tang J, Xia F, Wu J, Zeng R . Quantitative Phosphoproteomics Revealed Glucose-Stimulated Responses of Islet Associated with Insulin Secretion. J Proteome Res. 2015; 14(11):4635-46. DOI: 10.1021/acs.jproteome.5b00507. View

Dentin R, Hedrick S, Xie J, Yates 3rd J, Montminy M . Hepatic glucose sensing via the CREB coactivator CRTC2. Science. 2008; 319(5868):1402-5. DOI: 10.1126/science.1151363. View

Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H . Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007; 131(6):1190-203. DOI: 10.1016/j.cell.2007.11.025. View

Pohlentz G, Marx K, Mormann M . Characterization of Protein N-Glycosylation by Analysis of ZIC-HILIC-Enriched Intact Proteolytic Glycopeptides. Methods Mol Biol. 2015; 1394:163-179. DOI: 10.1007/978-1-4939-3341-9_12. View

10.

Shepherd P, Kahn B . Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. N Engl J Med. 1999; 341(4):248-57. DOI: 10.1056/NEJM199907223410406. View

11.

Chi A, Huttenhower C, Geer L, Coon J, Syka J, Bai D . Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry. Proc Natl Acad Sci U S A. 2007; 104(7):2193-8. PMC: 1892997. DOI: 10.1073/pnas.0607084104. View

12.

Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E . Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol (1985). 2005; 99(5):2008-19. DOI: 10.1152/japplphysiol.00660.2005. View

13.

Kirkpatrick D, Gerber S, Gygi S . The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications. Methods. 2005; 35(3):265-73. DOI: 10.1016/j.ymeth.2004.08.018. View

14.

Ruan H, Han X, Li M, Singh J, Qian K, Azarhoush S . O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metab. 2012; 16(2):226-37. PMC: 3480732. DOI: 10.1016/j.cmet.2012.07.006. View

15.

Hsu J, Huang S, Chow N, Chen S . Stable-isotope dimethyl labeling for quantitative proteomics. Anal Chem. 2003; 75(24):6843-52. DOI: 10.1021/ac0348625. View

16.

de Corte V, Demol H, Goethals M, Van Damme J, Gettemans J, Vandekerckhove J . Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach. Protein Sci. 1999; 8(1):234-41. PMC: 2144107. DOI: 10.1110/ps.8.1.234. View

17.

Vazquez E, Berthiaume J, Kamath V, Achike O, Buchanan E, Montano M . Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart. Cardiovasc Res. 2015; 107(4):453-65. PMC: 6279178. DOI: 10.1093/cvr/cvv183. View

18.

Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A . Role of advanced glycation end products in cellular signaling. Redox Biol. 2014; 2:411-29. PMC: 3949097. DOI: 10.1016/j.redox.2013.12.016. View

19.

Zhang Y, Askenazi M, Jiang J, Luckey C, Griffin J, Marto J . A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia. Mol Cell Proteomics. 2009; 9(5):780-90. PMC: 2871413. DOI: 10.1074/mcp.M900452-MCP200. View

20.

Szabat M, Lynn F, Hoffman B, Kieffer T, Allan D, Johnson J . Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes. 2012; 61(6):1365-71. PMC: 3357305. DOI: 10.2337/db11-1361. View