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A Potent Excitatory Input to the Nucleus Locus Coeruleus from the Ventrolateral Medulla

Overview
Journal Neurosci Lett
Specialty Neurology
Date 1986 Nov 21
PMID 3025783
Citations 28
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Abstract

Our recent anatomic experiments reveal major innervation of the nucleus locus coeruleus (LC) from the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla. In the present studies, low intensity, single pulse electrical stimulation of the PGi synaptically activated most LC neurons examined (69%), while a smaller percentage of LC cells (20%) exhibited pure inhibitory responses. Pharmacologic experiments suggest that the excitatory response may be mediated by an amino acid transmitter.

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