Osteogenesis and Aging: Lessons from Mesenchymal Stem Cells

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2018 Sep 28

PMID 30257716

Citations 136

Authors

Arantza Infante

Clara I Rodriguez

Affiliations

Soon will be listed here.

Abstract

Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process.

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