The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders

Overview

Journal Curr Neurol Neurosci Rep

Specialty Neurology

Date 2018 Sep 26

PMID 30251184

Citations 94

Authors

Heather K Hughes

Destanie Rose

Paul Ashwood

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: There is a growing body of evidence indicating the gut microbiota influence neurodevelopment and behavior. The purposes of this review are to provide an overview of studies analyzing the microbiota and their metabolites in autism spectrum disorders (ASD) and to discuss the possible mechanisms of action involved in microbial influence on the brain and behavior.

Recent Findings: The microbiota-gut-brain (MGB) axis has been extensively studied in animal models, and it is clear that alterations in the composition of microbiota alter neurological and behavioral outcomes. However, findings in human studies are less abundant. Although there are several studies so far showing altered microbiota (dysbiosis) in ASD, the results are heterogeneous and often contradictory. Intervention studies such as fecal microbiota transplant therapies show promise and lend credence to the involvement of the microbiota in ASD. A role for the microbiota in ASD is likely; however, further studies elucidating microbial or metabolomic signatures and mechanisms of action are needed. Future research should focus on intervention studies that can identify specific metabolites and immune mediators that improve with treatment to help identify etiologies and pathological mechanisms of ASD.

Citing Articles

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References

OMahony S, Marchesi J, Scully P, Codling C, Ceolho A, Quigley E . Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry. 2008; 65(3):263-7. DOI: 10.1016/j.biopsych.2008.06.026. View

Rose D, Yang H, Serena G, Sturgeon C, Ma B, Careaga M . Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun. 2018; 70:354-368. PMC: 5953830. DOI: 10.1016/j.bbi.2018.03.025. View

Iovene M, Bombace F, Maresca R, Sapone A, Iardino P, Picardi A . Intestinal Dysbiosis and Yeast Isolation in Stool of Subjects with Autism Spectrum Disorders. Mycopathologia. 2016; 182(3-4):349-363. DOI: 10.1007/s11046-016-0068-6. View

Raz R, Roberts A, Lyall K, Hart J, Just A, Laden F . Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy: a nested case-control analysis within the Nurses' Health Study II Cohort. Environ Health Perspect. 2014; 123(3):264-70. PMC: 4348742. DOI: 10.1289/ehp.1408133. View

Dieme B, Mavel S, Blasco H, Tripi G, Bonnet-Brilhault F, Malvy J . Metabolomics Study of Urine in Autism Spectrum Disorders Using a Multiplatform Analytical Methodology. J Proteome Res. 2015; 14(12):5273-82. DOI: 10.1021/acs.jproteome.5b00699. View

Kelly C, Zheng L, Campbell E, Saeedi B, Scholz C, Bayless A . Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015; 17(5):662-71. PMC: 4433427. DOI: 10.1016/j.chom.2015.03.005. View

Erb Downward J, Falkowski N, Mason K, Muraglia R, Huffnagle G . Modulation of post-antibiotic bacterial community reassembly and host response by Candida albicans. Sci Rep. 2013; 3:2191. PMC: 3709164. DOI: 10.1038/srep02191. View

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Toth M . The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014; 6(263):263ra158. PMC: 4396848. DOI: 10.1126/scitranslmed.3009759. View

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P . Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 504(7480):451-5. PMC: 3869884. DOI: 10.1038/nature12726. View

10.

Kang D, Park J, Ilhan Z, Wallstrom G, LaBaer J, Adams J . Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS One. 2013; 8(7):e68322. PMC: 3700858. DOI: 10.1371/journal.pone.0068322. View

11.

Xiong X, Liu D, Wang Y, Zeng T, Peng Y . Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. Biomed Res Int. 2016; 2016:9485412. PMC: 4829699. DOI: 10.1155/2016/9485412. View

12.

Noto A, Fanos V, Barberini L, Grapov D, Fattuoni C, Zaffanello M . The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings. J Matern Fetal Neonatal Med. 2014; 27 Suppl 2:46-52. DOI: 10.3109/14767058.2014.954784. View

13.

Song Y, Liu C, Finegold S . Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol. 2004; 70(11):6459-65. PMC: 525120. DOI: 10.1128/AEM.70.11.6459-6465.2004. View

14.

Cryan J, Dinan T . Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012; 13(10):701-12. DOI: 10.1038/nrn3346. View

15.

Atladottir H, Henriksen T, Schendel D, Parner E . Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics. 2012; 130(6):e1447-54. PMC: 4451062. DOI: 10.1542/peds.2012-1107. View

16.

Finegold S, Dowd S, Gontcharova V, Liu C, Henley K, Wolcott R . Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe. 2010; 16(4):444-53. DOI: 10.1016/j.anaerobe.2010.06.008. View

17.

Liang S, Wang T, Hu X, Luo J, Li W, Wu X . Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience. 2015; 310:561-77. DOI: 10.1016/j.neuroscience.2015.09.033. View

18.

Gevi F, Zolla L, Gabriele S, Persico A . Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism. Mol Autism. 2016; 7:47. PMC: 5121959. DOI: 10.1186/s13229-016-0109-5. View

19.

Williams B, Hornig M, Buie T, Bauman M, Paik M, Wick I . Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One. 2011; 6(9):e24585. PMC: 3174969. DOI: 10.1371/journal.pone.0024585. View

20.

Vuong H, Yano J, Fung T, Hsiao E . The Microbiome and Host Behavior. Annu Rev Neurosci. 2017; 40:21-49. PMC: 6661159. DOI: 10.1146/annurev-neuro-072116-031347. View