Conditioned Aversive Responses Produced by Delayed, but Not Immediate, Exposure to Cocaine and Morphine in Male Sprague-Dawley Rats

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2018 Sep 26

PMID 30251163

Citations 1

Authors

Kelsey G Guenther

Cassidy E Wideman

Erin M Rock

Cheryl L Limebeer

Linda A Parker

Affiliations

Soon will be listed here.

Abstract

Rationale: To determine the conditions under which tastes paired with delayed access to experimenter-delivered cocaine and morphine elicit a conditionally aversive affective state.

Objectives And Methods: The potential of saccharin paired with immediate access to cocaine (5, 10, 20 mg/kg, sc and ip) and delayed (30 and 10 min) access to cocaine (20 mg/kg, sc and ip) and morphine (10 mg/kg, sc) to elicit a pattern of aversive responding in the taste reactivity test (Grill and Norgren 1978a) was evaluated. Cocaine-induced aversions were compared with those produced by a moderate dose of LiCl (50 mg/kg). Finally, as an independent measure of cocaine withdrawal, the potential of exposure to saccharin paired with delayed access to cocaine to produce anxiogenic-like responding in the Light-Dark Emersion test was evaluated.

Results: Immediate access to cocaine did not produce conditioned aversion at any dose. Delayed (30 or 10 min) access to sc cocaine (20 mg/kg) produced robust conditioned aversion and delayed access to ip cocaine (20 mg/kg; 30 min) and to sc morphine (10 mg/kg; 10 min) produced weaker conditioned aversion. Yawning emerged as a potential withdrawal response in rats conditioned with delayed (30 min) access to 20 mg/kg, sc, cocaine. Contextual cues did not produce conditioned aversion when paired with delayed access to sc cocaine (20 mg/kg). Finally, exposure to saccharin paired with delayed access to cocaine produced anxiogenic-like responding in the Light-Dark Emersion test.

Conclusion: Our results support the contention that a conditioned aversive state develops when a taste cue comes to predict the delayed availability of drugs of abuse.

Citing Articles

Impact of the Aversive Effects of Drugs on Their Use and Abuse.

Riley A, Manke H, Huang S Behav Neurol. 2022; 2022:8634176.

PMID: 35496768 PMC: 9045991. DOI: 10.1155/2022/8634176.

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