CHMP4C: A Novel Regulator of the Mitotic Spindle Checkpoint

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2018 Sep 26

PMID 30250900

Citations 5

Authors

Eleni Petsalaki

George Zachos

Affiliations

Soon will be listed here.

Abstract

The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport (ESCRT) machinery, protects human cells against chromosome missegregation by promoting localisation of the ROD-ZW10-ZWILCH (RZZ) spindle checkpoint complex to unattached kinetochores.

Citing Articles

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Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target.

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CHMP4C as a novel marker regulates prostate cancer progression through cycle pathways and contributes to immunotherapy.

Zhang H, Liu D, Qin Z, Yi B, Zhu L, Xu S Front Oncol. 2023; 13:1170397.

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Using to Analyse the Human Paralogs of the ESCRT-III Core Component Shrub/CHMP4/Snf7 and Its Interactions with Members of the LGD/CC2D1 Family.

Baeumers M, Schulz K, Klein T Int J Mol Sci. 2022; 23(14).

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CHMP4C regulates lung squamous carcinogenesis and progression through cell cycle pathway.

Liu B, Guo S, Li G, Liu Y, Liu X, Yue J J Thorac Dis. 2021; 13(8):4762-4774.

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