Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis and Proliferation in Colorectal Carcinoma

Overview

Journal Oncol Lett

Specialty Oncology

Date 2018 Sep 26

PMID 30250600

Citations 11

Authors

Lu Han

Yong Jiang

Dongxing Han

Weilin Tan

Affiliations

Soon will be listed here.

Abstract

The primary factor associated with poor survival rate in patients with colorectal carcinoma (CRC) is the presence of metastasis. The underlying molecular mechanisms of CRC metastasis are yet to be fully elucidated. The present study investigated the function of heat shock protein 27 (Hsp27) on the invasion and proliferation of CRC cells. The clinical significance of Hsp27 was evaluated using tissue microarray analysis (n=81). Invasion and metastasis assays were used to determine the function of Hsp27 in CRC metastasis and using RNA interference and the ectopic expression of Hsp27. The upregulation of Hsp27 has been frequently identified in CRC tissues. Patients with CRC and a high expression level of Hsp27 have a reduced overall survival rate. Silencing Hsp27 inhibited the growth and invasion of CRC cells and , whereas ectopic overexpression of Hsp27 promoted the proliferation and invasion of CRC cells . Furthermore, depletion of Hsp27 expression inhibited the epithelial-to-mesenchymal transition (EMT), whilst ectopic overexpression of Hsp27 induced EMT. The results of the present study indicated that Hsp27 serves an important function in the aggressiveness of CRC through inducing EMT. Hsp27 suppression may represent a potential therapeutic option for the suppression of CRC progression.

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