The Ace Locus of Drosophila Melanogaster: Structural Gene for Acetylcholinesterase with an Unusual 5' Leader

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1986 Nov 1

PMID 3024971

Citations 55

Authors

L M Hall

P Spierer

Affiliations

Soon will be listed here.

Abstract

The Ace locus of Drosophila melanogaster has been mapped at the molecular level. cDNA clones from the locus have been isolated and their sequence determined, confirming that Ace forms the structural gene for acetylcholinesterase (AChE). The cDNAs have a 1950 nucleotide open reading frame from which the complete amino acid sequence of AChE has been deduced. The Drosophila enzyme is found to have extensive homology to the known sequence of Torpedo AChE. Ace cDNAs have an unusual structure with a long 5' leader and several short upstream open reading frames.

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