Stem Cells and the Bird Cochlea-Where Is Everybody?

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2018 Sep 26

PMID 30249599

Citations 14

Authors

Amanda S Janesick

Stefan Heller

Affiliations

Soon will be listed here.

Abstract

In sharp contrast to the adult mammalian cochlea, which lacks regenerative ability, the mature avian cochlea, or basilar papilla (BP) is capable of complete recovery from hearing loss after damage. Avian sensory hair cell regeneration relies on rousing quiescent supporting cells to proliferate or transdifferentiate after hair cell death. Unlike mammalian cochlear supporting cells, which have clearly defined subtypes, avian BP supporting cells are deceptively indistinguishable and molecular markers have yet to be identified. Despite the importance of supporting cells as the putative stem cells in avian regeneration, it is unknown whether all supporting cells possess equal capability to give rise to a hair cell or if a specialized subpopulation exists. In this perspective, we reinvigorate the concept of a stem cell in the BP, and form comparisons to other regenerating tissues that show cell-cycle reentry after damage. Special emphasis is given to the structure of the BP and how anatomy informs both the potential, intrinsic heterogeneity of the supporting cell layer as well as the choice between mitotic and nonmitotic regenerative strategies.

Citing Articles

Protocol for in vivo elimination of avian auditory hair cells, multiplexed mRNA detection, immunohistochemistry, and S-phase labeling.

Sato M, Huang A, Heller S, Benkafadar N STAR Protoc. 2024; 5(2):103118.

PMID: 38852155 PMC: 11217775. DOI: 10.1016/j.xpro.2024.103118.

Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ.

Sato M, Benkafadar N, Heller S Cell Rep. 2024; 43(3):113822.

PMID: 38393948 PMC: 11068303. DOI: 10.1016/j.celrep.2024.113822.

An essential signaling cascade for avian auditory hair cell regeneration.

Benkafadar N, Sato M, Ling A, Janesick A, Scheibinger M, Jan T Dev Cell. 2023; 59(2):280-291.e5.

PMID: 38128539 PMC: 11681615. DOI: 10.1016/j.devcel.2023.11.028.

Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium.

Matsunaga M, Yamamoto R, Kita T, Ohnishi H, Yamamoto N, Okano T iScience. 2023; 26(2):106046.

PMID: 36818302 PMC: 9932131. DOI: 10.1016/j.isci.2023.106046.

Cell-type identity of the avian utricle.

Scheibinger M, Janesick A, Benkafadar N, Ellwanger D, Jan T, Heller S Cell Rep. 2022; 40(13):111432.

PMID: 36170825 PMC: 9588199. DOI: 10.1016/j.celrep.2022.111432.

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