Bio-monitoring of DNA Damage in Matchstick Industry Workers from Peshawar Khyber Pakhtunkhwa, Pakistan

Overview

Journal Int J Occup Environ Health

Specialty Environmental Health

Date 2018 Sep 25

PMID 30247095

Citations 2

Authors

Muhammad Khisroon

Ajmal Khan

Ubaid Ullah

Farrah Zaidi

Ahmadullah

Affiliations

Soon will be listed here.

Abstract

Background: Safety protocols are usually neglected in most of the matchstick industries rendering the laborer prone to various occupational hazards.

Objective: The present study highlights DNA damage among matchstick factory workers (n = 92) against a control group (n = 48) of healthy individuals.

Methods: Genotoxicity was measured in peripheral blood lymphocytes of the test subjects using a Single Cell Gel Electrophoresis assay (SCGE/comet assay).

Results: Our results substantiate a high Total Comet Score (TCS) for factory workers (74.5 ± 47.0) when compared to the control group (53.0 ± 25.0) (P ≤ 0.001). Age and duration of occupational exposure had no significant effect (P > 0.05) on TCS value. As for job function, the TCS value was greatest in sweepers (91.0 ± 56.1) and lowest in box-making operators (26.0 ± 25.0) indicating that waste disposal poses the higher risk of DNA damage.

Conclusions: Our study corroborates that matchstick chemicals can potentially damage the DNA of exposed subjects.

Citing Articles

Environmental impacts, water footprint and cumulative energy demand of match industry in Pakistan.

Ullah N, Bano S, Habiba U, Sabir M, Akhtar A, Ramzan S PLoS One. 2021; 16(5):e0251928.

PMID: 34015005 PMC: 8136843. DOI: 10.1371/journal.pone.0251928.

Biofortification of wheat with zinc for eliminating deficiency in Pakistan: study protocol for a cluster-randomised, double-blind, controlled effectiveness study (BIZIFED2).

Lowe N, Zaman M, Moran V, Ohly H, Sinclair J, Fatima S BMJ Open. 2020; 10(11):e039231.

PMID: 33208325 PMC: 7677336. DOI: 10.1136/bmjopen-2020-039231.

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