Design of a Multicompartment Hydrogel That Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2018 Sep 22

PMID 30240496

Citations 41

Authors

Poulami Majumder

Ulrich Baxa

Scott T R Walsh

Joel P Schneider

Affiliations

Soon will be listed here.

Abstract

There is significant current interest in identifying new combination therapies that synergize to treat disease, and it is becoming increasingly clear that the temporal resolution of their administration greatly impacts efficacy. To facilitate effective delivery, a multicompartment hydrogel material was developed that is composed of spherical vesicles interlaced within a self-assembled peptide-based network of physically crosslinked fibrils that allows time-resolved independent co-delivery of small molecules. This material architecture effectively delivers the EGFR kinase inhibitor Erlotinib (ERL) and Doxorubicin (DOX, DNA intercalator) in an ERL→DOX sequential manner to synergistically kill glioblastoma, the most aggressive form of brain cancer.

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