Progressive Reorganization of the Host Cell Cytoskeleton During Adenovirus Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1986 Dec 1

PMID 3023671

Citations 10

Authors

M Staufenbiel

P Epple

W Deppert

Affiliations

Soon will be listed here.

Abstract

Infection of cells with adenovirus lead to a characteristic reorganization of all cytoskeleton systems, starting with alterations at the microtubuli of the cells. During this progress, the flat, extended, and polar morphology of the cytoskeleton became nonpolar and rounder. These rearrangements were initiated before the appearance of adenovirus structural proteins hexon and fiber, as well as before the shutoff of host protein synthesis. We conclude that these alterations reflect a specific reorganization rather than an unorganized breakdown of the cell during adenovirus infection.

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