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Pediatric Pleomorphic Adenoma of the Parotid: Case Report, Review of Literature and Novel Therapeutic Targets

Overview
Specialty Health Services
Date 2018 Sep 21
PMID 30231590
Citations 3
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Abstract

Salivary gland tumors are extremely rare and encompass a diverse group of histologies. Less than 5% of the affected population is pediatric. We present a case of 6-year-old child with pleomorphic adenoma of the parotid. The patient underwent a superficial parotidectomy. Recurrence was not observed in the six months of follow-up. Surgery is the mainstay of the management of benign salivary gland tumors. Although novel molecular agents are being explored, personalized therapy would be a challenge due to the rarity and vast genetic/histologic variations of salivary gland tumors.

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References
1.
Chiaravalli S, Guzzo M, Bisogno G, Pasquale M, Migliorati R, De Leonardis F . Salivary gland carcinomas in children and adolescents: the Italian TREP project experience. Pediatr Blood Cancer. 2014; 61(11):1961-8. DOI: 10.1002/pbc.25139. View

2.
Ellies M, Laskawi R . Diseases of the salivary glands in infants and adolescents. Head Face Med. 2010; 6:1. PMC: 2831878. DOI: 10.1186/1746-160X-6-1. View

3.
Gontarz M, Wyszynska-Pawelec G, Zapala J . Primary epithelial salivary gland tumours in children and adolescents. Int J Oral Maxillofac Surg. 2017; 47(1):11-15. DOI: 10.1016/j.ijom.2017.06.004. View

4.
Ho A, Pfister D . Challenges and Opportunities for Developing New Therapeutics for Salivary Gland Cancers. J Oncol Pract. 2018; 14(2):109-110. DOI: 10.1200/JOP.18.00039. View

5.
Goyal G, Mehdi S, Ganti A . Salivary Gland Cancers: Biology and Systemic Therapy. Oncology (Williston Park). 2015; 29(10):773-80. View