Chromosome Positioning and Male Infertility: It Comes with the Territory

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2018 Sep 20

PMID 30229502

Citations 6

Authors

Zaida Sarrate

Mireia Sole

Francesca Vidal

Ester Anton

Joan Blanco

Affiliations

Soon will be listed here.

Abstract

The production of functional spermatozoa through spermatogenesis requires a spatially and temporally highly regulated gene expression pattern, which in case of alterations, leads to male infertility. Changes of gene expression by chromosome anomalies, gene variants, and epigenetic alterations have been described as the main genetic causes of male infertility. Recent molecular and cytogenetic approaches have revealed that higher order chromosome positioning is essential for basic genome functions, including gene expression. This review addresses this issue by exposing well-founded evidences which support that alterations on the chromosome topology in spermatogenetic cells leads to defective sperm function and could be considered as an additional genetic cause of male infertility.

Citing Articles

Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa.

Martinez G, Cappetta D, Telesca M, Urbanek K, Castaldo G, Dhellemmes M Int J Biol Sci. 2023; 19(7):2234-2255.

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Chromosome Territories in Hematological Malignancies.

Lima M, Lisboa M, Terceiro L, Rangel-Pozzo A, Mai S Cells. 2022; 11(8).

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How much, if anything, do we know about sperm chromosomes of Robertsonian translocation carriers?.

Wiland E, Olszewska M, Wozniak T, Kurpisz M Cell Mol Life Sci. 2020; 77(23):4765-4785.

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Human Sperm Chromosomes: To Form Hairpin-Loops, Or Not to Form Hairpin-Loops, That Is the Question.

Ioannou D, Tempest H Genes (Basel). 2019; 10(7).

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Meiotic behavior of a complex hexavalent in heterozygous mice for Robertsonian translocations: insights for synapsis dynamics.

Ribagorda M, Berrios S, Solano E, Ayarza E, Martin-Ruiz M, Gil-Fernandez A Chromosoma. 2019; 128(2):149-163.

PMID: 30826871 DOI: 10.1007/s00412-019-00695-8.

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