Cystic Fibrosis Related Diabetes: a Unique Challenge in Diabetes Care

Overview

Journal Mo Med

Specialty General Medicine

Date 2018 Sep 20

PMID 30228505

Citations 3

Authors

Marina Litvin

Schola Nwachukwu

Affiliations

Soon will be listed here.

Abstract

Cystic Fibrosis (CF) is a common autosomal recessive disease that affects multiple organs due to a defect in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). This transporter is present in various organs and tissues, including the airway epithelium, sinuses, pancreas, intestine, biliary tree, the vas deferens, and the sweat ducts, making CF a multi-system disease1. As CF patients are living longer, pancreatic function declines and diabetes emerges, further complicating the nutritional status and care of these patients.

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References

Hillman M, Eriksson L, Mared L, Helgesson K, Landin-Olsson M . Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus. J Cyst Fibros. 2011; 11(2):144-9. DOI: 10.1016/j.jcf.2011.11.001. View

Spoonhower K, Davis P . Epidemiology of Cystic Fibrosis. Clin Chest Med. 2016; 37(1):1-8. DOI: 10.1016/j.ccm.2015.10.002. View

Battezzati A, Mari A, Zazzeron L, Alicandro G, Claut L, Battezzati P . Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients. Eur J Endocrinol. 2011; 165(1):69-76. DOI: 10.1530/EJE-10-1003. View

Sequeiros I, Jarad N . Factors associated with a shorter time until the next pulmonary exacerbation in adult patients with cystic fibrosis. Chron Respir Dis. 2012; 9(1):9-16. DOI: 10.1177/1479972311433575. View

Ballmann M, Hubert D, Assael B, Kronfeld K, Honer M, Holl R . Open randomised prospective comparative multi-centre intervention study of patients with cystic fibrosis and early diagnosed diabetes mellitus. BMC Pediatr. 2014; 14:70. PMC: 3975280. DOI: 10.1186/1471-2431-14-70. View

Lanng S, Thorsteinsson B, Erichsen G, Nerup J, Koch C . Glucose tolerance in cystic fibrosis. Arch Dis Child. 1991; 66(5):612-6. PMC: 1792959. DOI: 10.1136/adc.66.5.612. View

Borowitz D, Robinson K, Rosenfeld M, Davis S, Sabadosa K, Spear S . Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis. J Pediatr. 2009; 155(6 Suppl):S73-93. PMC: 6324931. DOI: 10.1016/j.jpeds.2009.09.001. View

Boyle M . Nonclassic cystic fibrosis and CFTR-related diseases. Curr Opin Pulm Med. 2003; 9(6):498-503. DOI: 10.1097/00063198-200311000-00009. View

Pezzulo A, Tang X, Hoegger M, Abou Alaiwa M, Ramachandran S, Moninger T . Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature. 2012; 487(7405):109-13. PMC: 3390761. DOI: 10.1038/nature11130. View

10.

Cano Megias M, Gonzalez Albarran O . Cystic fibrosis-related diabetes: a distinct condition. Endocrinol Nutr. 2014; 62(1):38-44. DOI: 10.1016/j.endonu.2014.06.010. View

11.

Bellin M, Laguna T, Leschyshyn J, Regelmann W, Dunitz J, Billings J . Insulin secretion improves in cystic fibrosis following ivacaftor correction of CFTR: a small pilot study. Pediatr Diabetes. 2013; 14(6):417-21. PMC: 3804832. DOI: 10.1111/pedi.12026. View

12.

Perano S, Rayner C, Couper J, Martin J, Horowitz M . Cystic fibrosis related diabetes--a new perspective on the optimal management of postprandial glycemia. J Diabetes Complications. 2014; 28(6):904-11. DOI: 10.1016/j.jdiacomp.2014.06.012. View

13.

Tierney S, Webb K, Jones A, Dodd M, McKenna D, Rowe R . Living with cystic fibrosis-related diabetes or type 1 diabetes mellitus: a comparative study exploring health-related quality of life and patients' reported experiences of hypoglycaemia. Chronic Illn. 2008; 4(4):278-88. DOI: 10.1177/1742395308094240. View

14.

Quon B, Rowe S . New and emerging targeted therapies for cystic fibrosis. BMJ. 2016; 352:i859. PMC: 4817245. DOI: 10.1136/bmj.i859. View

15.

Ode K, Moran A . New insights into cystic fibrosis-related diabetes in children. Lancet Diabetes Endocrinol. 2014; 1(1):52-8. DOI: 10.1016/S2213-8587(13)70015-9. View

16.

van den Berg J, Morton A, Kok S, Pijl H, Conway S, Heijerman H . Microvascular complications in patients with cystic fibrosis-related diabetes (CFRD). J Cyst Fibros. 2008; 7(6):515-9. DOI: 10.1016/j.jcf.2008.05.008. View

17.

Ziai S, Coriati A, Gauthier M, Rabasa-Lhoret R, Richter M . Could T cells be involved in lung deterioration and hyperglycemia in cystic fibrosis?. Diabetes Res Clin Pract. 2014; 105(1):22-9. DOI: 10.1016/j.diabres.2014.03.002. View

18.

Haq I, Gray M, Garnett J, Ward C, Brodlie M . Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets. Thorax. 2016; 71(3):284-7. DOI: 10.1136/thoraxjnl-2015-207588. View

19.

Augarten A, Ben Tov A, Madgar I, Barak A, Akons H, Laufer J . The changing face of the exocrine pancreas in cystic fibrosis: the correlation between pancreatic status, pancreatitis and cystic fibrosis genotype. Eur J Gastroenterol Hepatol. 2008; 20(3):164-8. DOI: 10.1097/MEG.0b013e3282f36d04. View

20.

OShea D, OConnell J . Cystic fibrosis related diabetes. Curr Diab Rep. 2014; 14(8):511. DOI: 10.1007/s11892-014-0511-3. View