Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Sep 20

PMID 30227629

Citations 30

Authors

Sungmin Lee

Beomseok Son

Gaeul Park

Hyunwoo Kim

Hyunkoo Kang

Jaewan Jeon

Hyesook Youn

Buhyun Youn

Affiliations

Soon will be listed here.

Abstract

Hyperthermia is a cancer treatment where tumor tissue is heated to around 40 °C. Hyperthermia shows both cancer cell cytotoxicity and immune response stimulation via immune cell activation. Immunogenic responses encompass the innate and adaptive immune systems, involving the activation of macrophages, natural killer cells, dendritic cells, and T cells. Moreover, hyperthermia is commonly used in combination with different treatment modalities, such as radiotherapy and chemotherapy, for better clinical outcomes. In this review, we will focus on hyperthermia-induced immunogenic effects and molecular events to improve radiotherapy efficacy. The beneficial potential of integrating radiotherapy with hyperthermia is also discussed.

Citing Articles

Combined Radiotherapy and Hyperthermia: A Systematic Review of Immunological Synergies for Amplifying Radiation-Induced Abscopal Effects.

Van Dieren L, Quisenaerts T, Licata M, Beddok A, Lellouch A, Ysebaert D Cancers (Basel). 2024; 16(21).

PMID: 39518094 PMC: 11545184. DOI: 10.3390/cancers16213656.

Hyperthermia reduces cancer cell invasion and combats chemoresistance and immune evasion in human bladder cancer.

Tsai T, Hwang T, Chen P, Chen Y, Chou K, Ho C Int J Oncol. 2024; 65(6).

PMID: 39513598 PMC: 11575926. DOI: 10.3892/ijo.2024.5704.

A Case Report of Long-Term Survival Achieved by Nivolumab and Hyperthermia With Multiple Local Therapies for the Peritoneal Dissemination of Gastric Cancer.

Ohguri T, Tani S, Kawarada Y, Kitahara M Cureus. 2024; 16(9):e69147.

PMID: 39398851 PMC: 11467698. DOI: 10.7759/cureus.69147.

Hyperthermia and radiotherapy: physiological basis for a synergistic effect.

Righini M, Durham A, Tsoutsou P Front Oncol. 2024; 14:1428065.

PMID: 39165690 PMC: 11333208. DOI: 10.3389/fonc.2024.1428065.

Ultrasound Image Temperature Monitoring Based on a Temporal-Informed Neural Network.

Han Y, Du Y, He L, Meng X, Li M, Cao F Sensors (Basel). 2024; 24(15).

PMID: 39123982 PMC: 11314660. DOI: 10.3390/s24154934.

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