Aptamer Based Electrochemiluminescent Determination of Bisphenol A by Using Carboxylated Graphitic Carbon Nitride

Overview

Journal Mikrochim Acta

Specialties Biotechnology
Chemistry

Date 2018 Sep 19

PMID 30225568

Citations 5

Authors

Hai-Xia Cao

Li Wang

Chang-Gang Pan

Yu-Sheng He

Guo-Xi Liang

Affiliations

Soon will be listed here.

Abstract

An electrochemiluminescence (ECL) based assay is described for the determination of the endocrine disruptor bisphenol A (BPA). The method is based on the use of carboxylated graphitic carbon nitride (C-g-CN) carrying an immobilized aptamer against BPA. In the presence of BPA, the ECL signal decreases due to ECL energy transfer from excited-state C-g-CN to the BPA oxidation product. Under the optimal conditions, ECL intensity increases linearly in the 0.1 pM to 1 nM BPA concentration range. The detection limit is as low as 30 fM. The assay has excellent sensitivity, outstanding stability and high selectivity. It was applied to the determination of BPA in spiked water samples. Graphical abstract Aptamer modified carboxylated graphitic carbon nitride was synthesized and applied in an electrochemiluminescence-based aptasensor for bisphenol A.

Citing Articles

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